New insights for FOXO and cell-fate decision in HIV infection and HIV associated neurocognitive disorder

Min Cui, Yunlong Huang, Yong Zhao, Jialin C Zheng

Research output: Chapter in Book/Report/Conference proceedingChapter

14 Scopus citations

Abstract

Human immunodeficiency virus Type 1 (HIV-I) infection and associated diseases continue to represent major health problem worldwide.FOXO transcriptional factors play an important role in the regulation of cell apoptosis, cell cycle arrest, stress resistance, metabolism and differentiation.This chapter will discuss the diverse functions ofFOXO in different cell types including'l-cells, macrophages, neurons and astrocytes within the context ofHIV-I infection. Given the overwhelmingevidence that FOXO proteins influence the cell fate ofimmune cells and involve in the homeostasis ofthe central nervous system (CNS), we will also discuss the potential role ofFOXO factors in HIV-I -associated neurological disorders.

Original languageEnglish (US)
Title of host publicationForkhead Transcription Factors
Subtitle of host publicationVital Elements in Biology and Medicine
PublisherSpringer New York LLC
Pages143-159
Number of pages17
ISBN (Print)9781441915986
DOIs
StatePublished - 2009

Publication series

NameAdvances in Experimental Medicine and Biology
Volume665
ISSN (Print)0065-2598

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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