TY - CHAP
T1 - New insights for FOXO and cell-fate decision in HIV infection and HIV associated neurocognitive disorder
AU - Cui, Min
AU - Huang, Yunlong
AU - Zhao, Yong
AU - Zheng, Jialin C
PY - 2009
Y1 - 2009
N2 - Human immunodeficiency virus Type 1 (HIV-I) infection and associated diseases continue to represent major health problem worldwide.FOXO transcriptional factors play an important role in the regulation of cell apoptosis, cell cycle arrest, stress resistance, metabolism and differentiation.This chapter will discuss the diverse functions ofFOXO in different cell types including'l-cells, macrophages, neurons and astrocytes within the context ofHIV-I infection. Given the overwhelmingevidence that FOXO proteins influence the cell fate ofimmune cells and involve in the homeostasis ofthe central nervous system (CNS), we will also discuss the potential role ofFOXO factors in HIV-I -associated neurological disorders.
AB - Human immunodeficiency virus Type 1 (HIV-I) infection and associated diseases continue to represent major health problem worldwide.FOXO transcriptional factors play an important role in the regulation of cell apoptosis, cell cycle arrest, stress resistance, metabolism and differentiation.This chapter will discuss the diverse functions ofFOXO in different cell types including'l-cells, macrophages, neurons and astrocytes within the context ofHIV-I infection. Given the overwhelmingevidence that FOXO proteins influence the cell fate ofimmune cells and involve in the homeostasis ofthe central nervous system (CNS), we will also discuss the potential role ofFOXO factors in HIV-I -associated neurological disorders.
UR - http://www.scopus.com/inward/record.url?scp=77952481709&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77952481709&partnerID=8YFLogxK
U2 - 10.1007/978-1-4419-1599-3_11
DO - 10.1007/978-1-4419-1599-3_11
M3 - Chapter
C2 - 20429422
AN - SCOPUS:77952481709
SN - 9781441915986
T3 - Advances in Experimental Medicine and Biology
SP - 143
EP - 159
BT - Forkhead Transcription Factors
PB - Springer New York LLC
ER -