New insights into exosome mediated tumor-immune escape: Clinical perspectives and therapeutic strategies

Anup S. Pathania, Philip Prathipati, Kishore B. Challagundla

Research output: Contribution to journalReview articlepeer-review

Abstract

Recent advances in extracellular vesicle biology have uncovered a substantial role in maintaining cell homeostasis in health and disease conditions by mediating intercellular communication, thus catching the scientific community's attention worldwide. Extracellular microvesicles, some called exosomes, functionally transfer biomolecules such as proteins and non-coding RNAs from one cell to another, influencing the local environment's biology. Although numerous advancements have been made in treating cancer patients with immune therapy, controlling the disease remains a challenge in the clinic due to tumor-driven interference with the immune response and inability of immune cells to clear cancer cells from the body. The present review article discusses the recent findings and knowledge gaps related to the role of exosomes derived from tumors and the tumor microenvironment cells in tumor escape from immunosurveillance. Further, we highlight examples where exosomal non-coding RNAs influence immune cells' response within the tumor microenvironment and favor tumor growth and progression. Therefore, exosomes can be used as a therapeutic target for the treatment of human cancers.

Original languageEnglish (US)
Article number188624
JournalBiochimica et Biophysica Acta - Reviews on Cancer
Volume1876
Issue number2
DOIs
StatePublished - Dec 2021

Keywords

  • Cancer
  • Exosomes
  • Extracellular vesicle
  • Immune cell dysfunction
  • Immune evasion
  • Immunotherapy
  • LncRNA
  • microRNA

ASJC Scopus subject areas

  • Oncology
  • Genetics
  • Cancer Research

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