New nanoscale pulsatile drug delivery system

Xin Ming Liu; Bin Yang; Yu Lu Wang; Jin Ye Wang

doi:10.1021/cm0479335

New nanoscale pulsatile drug delivery system

Xin Ming Liu, Bin Yang, Yu Lu Wang, Jin Ye Wang

Pharmacology & Experimental Neuroscience (PEN)

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

A new type of photocontrolled, liposomal drug delivery system with a average diameter of 99.7 nm that can achieve zero-order, multi-pulsatile release, and sustained release was described. The cytotoxicity of this drag delivery system was examined using NIH3T3 cells. The synthetic phototrigger decreases the spontaneous release of drug and increases the stability of liposomes beyond what have been previously reported. The amount of drug released from liposomes can be controlled by maintaining the concentration of the cis isomer of AB lipid 1 by UV irradiation, and the release rate can be controlled by altering the incorporation ratio of AB lipid 1.

Original language	English (US)
Pages (from-to)	2792-2795
Number of pages	4
Journal	Chemistry of Materials
Volume	17
Issue number	11
DOIs	https://doi.org/10.1021/cm0479335
State	Published - May 31 2005

ASJC Scopus subject areas

Chemistry(all)
Chemical Engineering(all)
Materials Chemistry

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