New nanoscale pulsatile drug delivery system

Xin Ming Liu, Bin Yang, Yu Lu Wang, Jin Ye Wang

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


A new type of photocontrolled, liposomal drug delivery system with a average diameter of 99.7 nm that can achieve zero-order, multi-pulsatile release, and sustained release was described. The cytotoxicity of this drag delivery system was examined using NIH3T3 cells. The synthetic phototrigger decreases the spontaneous release of drug and increases the stability of liposomes beyond what have been previously reported. The amount of drug released from liposomes can be controlled by maintaining the concentration of the cis isomer of AB lipid 1 by UV irradiation, and the release rate can be controlled by altering the incorporation ratio of AB lipid 1.

Original languageEnglish (US)
Pages (from-to)2792-2795
Number of pages4
JournalChemistry of Materials
Issue number11
StatePublished - May 31 2005
Externally publishedYes

ASJC Scopus subject areas

  • General Chemistry
  • General Chemical Engineering
  • Materials Chemistry


Dive into the research topics of 'New nanoscale pulsatile drug delivery system'. Together they form a unique fingerprint.

Cite this