Next-Generation Sequencing in Equine Genomics

Jessica L. Petersen, Stephen J. Coleman

Research output: Contribution to journalReview article

Abstract

The sequencing and assembly of a reference genome for the horse has been revolutionary for investigation of horse health and performance. Next-generation sequencing (NGS) methods represent a second revolution in equine genomics. Researchers can align and compare DNA and RNA sequencing data to the reference genome to explore variation that may contribute or be attributed to disease. NGS has also facilitated the translation of research discovery to clinically relevant applications. This article discusses the history and development of NGS, details some of the available sequencing platforms, and describes currently available applications in the context of both discovery and clinical settings.

Original languageEnglish (US)
Pages (from-to)195-209
Number of pages15
JournalVeterinary Clinics of North America. Equine Practice
Volume36
Issue number2
DOIs
StatePublished - Aug 2020

Keywords

  • Equine
  • Genetic variation
  • Genomics
  • RNA sequencing
  • Transcriptome

ASJC Scopus subject areas

  • Equine

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