Nicotine enhances operant responding for qualitatively distinct reinforcers under maintenance and extinction conditions

Scott T. Barret, Rick A. Bevins

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Rationale Nicotine enhancement of reward has been implicated as an important contributor to tobacco addiction. Despite the attention that reward enhancement has received, the behavioral mechanisms whereby nicotine enhances operant responding remain largely unknown. The present study sought to extend previous work by evaluating the effects of nicotine on responding for two qualitatively different rewards (visual stimulation (VS) and 4% sucrose solution) under fixed-ratio (FR) maintenance and extinction conditions. Method Sprague-Dawley rats were trained to press an active lever for VS (Experiment 1) or 4% sucrose solution (Experiment 2) and evaluated over 15 sessions on a FR5 schedule of reinforcement. Nicotine (0.4 mg base/kg, SC) or saline were administered 5 min before each session; the alternate solution was given in the home cage after the session. The effects of nicotine on extinction responding were then assessed over 5 sessions and rats were divided into 4 groups based on drug of injection received during FR-maintenance and extinction phases (maintenance-extinction): Nic-Nic, Nic-Sal, Sal-Sal, and Sal-Nic. Results Nicotine increased active lever response rates for both VS and 4% sucrose under FR5 maintenance conditions. Nicotine also increased response rates in the Nic-Nic group relative to all other groups under extinction conditions in both experiments, though this effect had greater longevity following VS maintenance conditions than sucrose. Enhancement of responding during extinction does not appear dependent upon locomotor activation by nicotine.

Original languageEnglish (US)
Pages (from-to)9-15
Number of pages7
JournalPharmacology Biochemistry and Behavior
Volume114-115
DOIs
StatePublished - Nov 14 2013

Keywords

  • Extinction
  • Nicotine
  • Rats
  • Reward-enhancement

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

Fingerprint Dive into the research topics of 'Nicotine enhances operant responding for qualitatively distinct reinforcers under maintenance and extinction conditions'. Together they form a unique fingerprint.

  • Cite this