TY - JOUR
T1 - Nitric oxide production in acute gastroenteritis in Indian children
AU - Sowmyanarayanan, Thuppal Varadachari
AU - Natarajan, Sathish Kumar
AU - Ramachandran, Anup
AU - Sarkar, Rajiv
AU - Moses, Prabhakar Devarajan
AU - Simon, Anna
AU - Agarwal, Indira
AU - Christopher, Solomon
AU - Kang, Gagandeep
N1 - Funding Information:
The work was funded by the CMC Fluid Research Fund, Christian Medical College, Vellore, India.
PY - 2009/8
Y1 - 2009/8
N2 - This study compared nitric oxide (NO) levels in 110 children with, and 110 children without, infectious gastroenteritis. Post-infection intestinal function was assessed in a subset. At least one pathogen was identified in 47.2% of cases. The most common diarrhoeal pathogens were rotavirus (22.7%) and norovirus genogroup II (11.8%). The levels of NO measured by median urinary nitrite:creatinine ratio were significantly higher in children with diarrhoea [23.6; interquartile range (IQR) 12.3-46.7] than without diarrhoea (7.8; IQR 4.1-13.2), P < 0.001. The ratio was not significantly different between diarrhoeal cases with and without pathogens (P = 0.148). Six of twelve children tested had intestinal dysfunction.
AB - This study compared nitric oxide (NO) levels in 110 children with, and 110 children without, infectious gastroenteritis. Post-infection intestinal function was assessed in a subset. At least one pathogen was identified in 47.2% of cases. The most common diarrhoeal pathogens were rotavirus (22.7%) and norovirus genogroup II (11.8%). The levels of NO measured by median urinary nitrite:creatinine ratio were significantly higher in children with diarrhoea [23.6; interquartile range (IQR) 12.3-46.7] than without diarrhoea (7.8; IQR 4.1-13.2), P < 0.001. The ratio was not significantly different between diarrhoeal cases with and without pathogens (P = 0.148). Six of twelve children tested had intestinal dysfunction.
KW - Acute gastroenteritis
KW - Children
KW - India
KW - Intestinal permeability
KW - Nitric oxide
KW - Rotavirus
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U2 - 10.1016/j.trstmh.2009.05.003
DO - 10.1016/j.trstmh.2009.05.003
M3 - Article
C2 - 19552932
AN - SCOPUS:67649859268
SN - 0035-9203
VL - 103
SP - 849
EP - 851
JO - Transactions of the Royal Society of Tropical Medicine and Hygiene
JF - Transactions of the Royal Society of Tropical Medicine and Hygiene
IS - 8
ER -