Nitric oxide production in acute gastroenteritis in Indian children

Thuppal Varadachari Sowmyanarayanan; Sathish Kumar Natarajan; Anup Ramachandran; Rajiv Sarkar; Prabhakar Devarajan Moses; Anna Simon; Indira Agarwal; Solomon Christopher; Gagandeep Kang

doi:10.1016/j.trstmh.2009.05.003

Nitric oxide production in acute gastroenteritis in Indian children

Thuppal Varadachari Sowmyanarayanan, Sathish Kumar Natarajan, Anup Ramachandran, Rajiv Sarkar, Prabhakar Devarajan Moses, Anna Simon, Indira Agarwal, Solomon Christopher, Gagandeep Kang

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

This study compared nitric oxide (NO) levels in 110 children with, and 110 children without, infectious gastroenteritis. Post-infection intestinal function was assessed in a subset. At least one pathogen was identified in 47.2% of cases. The most common diarrhoeal pathogens were rotavirus (22.7%) and norovirus genogroup II (11.8%). The levels of NO measured by median urinary nitrite:creatinine ratio were significantly higher in children with diarrhoea [23.6; interquartile range (IQR) 12.3-46.7] than without diarrhoea (7.8; IQR 4.1-13.2), P < 0.001. The ratio was not significantly different between diarrhoeal cases with and without pathogens (P = 0.148). Six of twelve children tested had intestinal dysfunction.

Original language	English (US)
Pages (from-to)	849-851
Number of pages	3
Journal	Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume	103
Issue number	8
DOIs	https://doi.org/10.1016/j.trstmh.2009.05.003
State	Published - Aug 2009
Externally published	Yes

Keywords

Acute gastroenteritis
Children
India
Intestinal permeability
Nitric oxide
Rotavirus

ASJC Scopus subject areas

Parasitology
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/j.trstmh.2009.05.003

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title = "Nitric oxide production in acute gastroenteritis in Indian children",

abstract = "This study compared nitric oxide (NO) levels in 110 children with, and 110 children without, infectious gastroenteritis. Post-infection intestinal function was assessed in a subset. At least one pathogen was identified in 47.2% of cases. The most common diarrhoeal pathogens were rotavirus (22.7%) and norovirus genogroup II (11.8%). The levels of NO measured by median urinary nitrite:creatinine ratio were significantly higher in children with diarrhoea [23.6; interquartile range (IQR) 12.3-46.7] than without diarrhoea (7.8; IQR 4.1-13.2), P < 0.001. The ratio was not significantly different between diarrhoeal cases with and without pathogens (P = 0.148). Six of twelve children tested had intestinal dysfunction.",

keywords = "Acute gastroenteritis, Children, India, Intestinal permeability, Nitric oxide, Rotavirus",

author = "Sowmyanarayanan, {Thuppal Varadachari} and Natarajan, {Sathish Kumar} and Anup Ramachandran and Rajiv Sarkar and Moses, {Prabhakar Devarajan} and Anna Simon and Indira Agarwal and Solomon Christopher and Gagandeep Kang",

note = "Funding Information: The work was funded by the CMC Fluid Research Fund, Christian Medical College, Vellore, India. ",

year = "2009",

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doi = "10.1016/j.trstmh.2009.05.003",

language = "English (US)",

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AU - Natarajan, Sathish Kumar

AU - Ramachandran, Anup

AU - Sarkar, Rajiv

AU - Moses, Prabhakar Devarajan

AU - Simon, Anna

AU - Agarwal, Indira

AU - Christopher, Solomon

AU - Kang, Gagandeep

N1 - Funding Information: The work was funded by the CMC Fluid Research Fund, Christian Medical College, Vellore, India.

PY - 2009/8

Y1 - 2009/8

N2 - This study compared nitric oxide (NO) levels in 110 children with, and 110 children without, infectious gastroenteritis. Post-infection intestinal function was assessed in a subset. At least one pathogen was identified in 47.2% of cases. The most common diarrhoeal pathogens were rotavirus (22.7%) and norovirus genogroup II (11.8%). The levels of NO measured by median urinary nitrite:creatinine ratio were significantly higher in children with diarrhoea [23.6; interquartile range (IQR) 12.3-46.7] than without diarrhoea (7.8; IQR 4.1-13.2), P < 0.001. The ratio was not significantly different between diarrhoeal cases with and without pathogens (P = 0.148). Six of twelve children tested had intestinal dysfunction.

AB - This study compared nitric oxide (NO) levels in 110 children with, and 110 children without, infectious gastroenteritis. Post-infection intestinal function was assessed in a subset. At least one pathogen was identified in 47.2% of cases. The most common diarrhoeal pathogens were rotavirus (22.7%) and norovirus genogroup II (11.8%). The levels of NO measured by median urinary nitrite:creatinine ratio were significantly higher in children with diarrhoea [23.6; interquartile range (IQR) 12.3-46.7] than without diarrhoea (7.8; IQR 4.1-13.2), P < 0.001. The ratio was not significantly different between diarrhoeal cases with and without pathogens (P = 0.148). Six of twelve children tested had intestinal dysfunction.

KW - Acute gastroenteritis

KW - Children

KW - India

KW - Intestinal permeability

KW - Nitric oxide

KW - Rotavirus

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Nitric oxide production in acute gastroenteritis in Indian children

Abstract

Keywords

ASJC Scopus subject areas

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