Nitric oxide production in acute gastroenteritis in Indian children

Thuppal Varadachari Sowmyanarayanan, Sathish Kumar Natarajan, Anup Ramachandran, Rajiv Sarkar, Prabhakar Devarajan Moses, Anna Simon, Indira Agarwal, Solomon Christopher, Gagandeep Kang

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


This study compared nitric oxide (NO) levels in 110 children with, and 110 children without, infectious gastroenteritis. Post-infection intestinal function was assessed in a subset. At least one pathogen was identified in 47.2% of cases. The most common diarrhoeal pathogens were rotavirus (22.7%) and norovirus genogroup II (11.8%). The levels of NO measured by median urinary nitrite:creatinine ratio were significantly higher in children with diarrhoea [23.6; interquartile range (IQR) 12.3-46.7] than without diarrhoea (7.8; IQR 4.1-13.2), P < 0.001. The ratio was not significantly different between diarrhoeal cases with and without pathogens (P = 0.148). Six of twelve children tested had intestinal dysfunction.

Original languageEnglish (US)
Pages (from-to)849-851
Number of pages3
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Issue number8
StatePublished - Aug 2009
Externally publishedYes


  • Acute gastroenteritis
  • Children
  • India
  • Intestinal permeability
  • Nitric oxide
  • Rotavirus

ASJC Scopus subject areas

  • Parasitology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases


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