Abstract
The relationship between average and peak personal exposure to nitrogen dioxide and urinary excretion of hydroxyproline and desmosine was investigated in a population of preschool children and their mothers. Weekly average personal nitrogen dioxide exposures for subjects who resided in homes with one or more potential nitrogen dioxide source (e.g., a kerosene space heater, gas stove, or tobacco smoke) ranged between 16.3 and 50.6 ppb (30.6 and 95.1 &m3) for children and between 16.9 and 44.1 ppb (12.8 and 82.9 &m3) for mothers. In these individuals, the hydroxyproline-to-creatinine and desmosine-to-creatinine ratios were unrelated to personal nitrogen dioxide exposure- even though continuous monitoring documented home nitrogen dioxide concentration peaks of 100-475 ppb lasting up to 100 h in duration. Significantly higher hydroxyproline-to-creatinine and desmosine-to-creatinine ratios were observed in children, compared with mothers @ <.001 and.003, respectively).
Original language | English (US) |
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Pages (from-to) | 376-384 |
Number of pages | 9 |
Journal | Archives of environmental health |
Volume | 47 |
Issue number | 5 |
DOIs | |
State | Published - 1992 |
Externally published | Yes |
ASJC Scopus subject areas
- Environmental Chemistry
- General Environmental Science
- Public Health, Environmental and Occupational Health
- Health, Toxicology and Mutagenesis