Non-24-hour sleep-wake syndrome following a car accident

Diane B. Boivin, F. O. James, J. B. Santo, O. Caliyurt, C. Chalk

Research output: Contribution to journalArticlepeer-review

57 Scopus citations


The authors report the case of a 39-year-old sighted woman who displayed non-24-hour sleep-wake cycles following a car accident. The phase relationship between endogenous circadian markers such as plasma melatonin and 6-sulfatoxymelatonin rhythms and self-selected sleep times was abnormal. A laboratory investigation indicated that she was sensitive to bright light as a circadian synchronizer. MRI and brain CT scans were normal, but microscopic brain damage in the vicinity of the suprachiasmatic nucleus or its output pathways is plausible.

Original languageEnglish (US)
Pages (from-to)1841-1843
Number of pages3
Issue number11
StatePublished - Jun 10 2003
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology


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