Non-infectious thrombosis of the melody® valve: A tale of two cities

Andrew E. Schneider, Jeffrey W. Delaney, Allison K. Cabalka

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Bioprosthetic valve thrombosis is an uncommon complication. We report two young women with prior uncomplicated percutaneous pulmonary valve replacement (Melody®, Medtronic, Inc. Minneapolis, MN) who later developed symptomatic pulmonary emboli and pulmonary valve dysfunction without evidence of infection. Thrombophilia risk factors included oral contraceptive use and mild thrombophilia. Both experienced recovery of valve function following anticoagulation. Acute changes in Melody® valve function should prompt a thorough investigation for and treatment of potential thrombotic causes.

Original languageEnglish (US)
Pages (from-to)600-604
Number of pages5
JournalCatheterization and Cardiovascular Interventions
Issue number4
StatePublished - Oct 1 2016


  • bioprosthetic valve thrombosis
  • factor V Leiden
  • pulmonary embolism
  • thrombophilia
  • thrombosis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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