Non-melanoma skin cancer and NSAID use in women with a history of skin cancer in the Women's Health Initiative

Ashley Wysong, Mina S. Ally, Christina S. Gamba, Manisha Desai, Susan M. Swetter, Kristina Seiffert-Sinha, Animesh A. Sinha, Marcia L. Stefanick, Jean Y. Tang

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Objective: Evidence for the effect of non-steroidal anti-inflammatory drugs (NSAIDs) on non-melanoma skin cancer (NMSC) risk is inconsistent. We prospectively examined whether regular, inconsistent, or no/low-use of NSAIDs is associated with lower NMSC risk among 54,728 postmenopausal Caucasian women in the Women's Health Initiative Observational Study enrolled between 1993 and 1998. Methods: Logistic regression models were used to assess odds of NMSC after adjusting for skin type, sun exposure history and indication for NSAID use. Results: There were 7652 incident cases of NMSC (median follow-up: 6.9 years). There was no association between regular NSAID-use and NMSC risk relative to no/low-users. However, in a subgroup analysis of 5325 women with a history of skin cancer (incident NMSC: 1897), odds of NMSC were lower among regular NSAID users whether < 5 years (OR 0.82, 95% CI: 0.70-0.95) or ≥ 5 years (OR 0.82, 95% CI: 0.69-0.98) of use compared to no/low-users. Inconsistent NSAID use and acetaminophen use were not associated with NMSC risk. Conclusion: Overall, NSAID use was not associated with NMSC risk. However, in women with a history of skin cancer, regular NSAID use was associated with 18% lower odds of NMSC. Future studies on potential chemopreventative effects of NSAIDs should focus on subjects with prior history of NMSC.

Original languageEnglish (US)
Pages (from-to)8-12
Number of pages5
JournalPreventive Medicine
Volume69
DOIs
StatePublished - Dec 2014

Keywords

  • Anti-inflammatory drugs
  • Aspirin
  • Female
  • Non-melanoma skin cancer
  • Non-steroidal

ASJC Scopus subject areas

  • Epidemiology
  • Public Health, Environmental and Occupational Health

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    Wysong, A., Ally, M. S., Gamba, C. S., Desai, M., Swetter, S. M., Seiffert-Sinha, K., Sinha, A. A., Stefanick, M. L., & Tang, J. Y. (2014). Non-melanoma skin cancer and NSAID use in women with a history of skin cancer in the Women's Health Initiative. Preventive Medicine, 69, 8-12. https://doi.org/10.1016/j.ypmed.2014.08.024