Abstract
Recent progress in biomaterial-based gene delivery systems has paved the way towards the effective treatment of human diseases originating from defective genes. Nucleic acid-based nanomedicine offers the advantage of increased safety, scalability, and flexibility to introduce modifications for targeted delivery. Numerous natural or synthetic cationic polymers and lipid carriers have greatly advanced the field of nucleic acid-based therapeutics. However, gene carrier based on single materials suffers from intrinsic deficiencies. Therefore, several hybrid systems by combining two or more kinds of materials are being explored and indeed provided thermodynamic stability, enhanced transfection efficiency and reduced cytotoxicity. This article highlights nucleic acid delivery facing various challenges and describes the advanced design elements used to overcome them.
| Original language | English (US) |
|---|---|
| Title of host publication | Comprehensive Biomaterials II |
| Publisher | Elsevier |
| Pages | 506-526 |
| Number of pages | 21 |
| ISBN (Electronic) | 9780081006924 |
| ISBN (Print) | 9780081006917 |
| DOIs | |
| State | Published - Jan 1 2017 |
Keywords
- Acids
- Cationic lipids
- Chitosan
- Dendrimers
- Nanoparticles
- Polyethyleneimine
- Polymethacrylates
ASJC Scopus subject areas
- General Engineering
- General Materials Science