Non-viral delivery of nucleic acid complexes

V. Kumar, D. Wen, R. I. Mahato

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Recent progress in biomaterial-based gene delivery systems has paved the way towards the effective treatment of human diseases originating from defective genes. Nucleic acid-based nanomedicine offers the advantage of increased safety, scalability, and flexibility to introduce modifications for targeted delivery. Numerous natural or synthetic cationic polymers and lipid carriers have greatly advanced the field of nucleic acid-based therapeutics. However, gene carrier based on single materials suffers from intrinsic deficiencies. Therefore, several hybrid systems by combining two or more kinds of materials are being explored and indeed provided thermodynamic stability, enhanced transfection efficiency and reduced cytotoxicity. This article highlights nucleic acid delivery facing various challenges and describes the advanced design elements used to overcome them.

Original languageEnglish (US)
Title of host publicationComprehensive Biomaterials II
PublisherElsevier
Pages506-526
Number of pages21
ISBN (Electronic)9780081006924
ISBN (Print)9780081006917
DOIs
StatePublished - Jan 1 2017

Keywords

  • Acids
  • Cationic lipids
  • Chitosan
  • Dendrimers
  • Nanoparticles
  • Polyethyleneimine
  • Polymethacrylates

ASJC Scopus subject areas

  • Engineering(all)
  • Materials Science(all)

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  • Cite this

    Kumar, V., Wen, D., & Mahato, R. I. (2017). Non-viral delivery of nucleic acid complexes. In Comprehensive Biomaterials II (pp. 506-526). Elsevier. https://doi.org/10.1016/B978-0-12-803581-8.09287-0