Noncoding RNAs as a Cause of Cancer

Juan Cui

doi:10.1016/B978-0-12-811022-5.00026-7

Noncoding RNAs as a Cause of Cancer

Juan Cui

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Noncoding RNAs (ncRNAs) are emerging as key regulators of tumorigenesis that control cancer-associated gene expression through microRNA-induced mRNA degradation or long ncRNA-mediated chromatin modification. They have been identified as highly promising cancer biomarkers through recent genome-wide association analysis, e.g., on single-nucleotide polymorphisms. This chapter will focus on the possible roles of ncRNA in causing cancer and review examples that also highlight the potential application of ncRNAs as diagnostic and prognostic biomarkers for cancer stratification and as therapeutic targets and agents for cancer treatment.

Original language	English (US)
Title of host publication	Cancer and Noncoding RNAs
Publisher	Elsevier
Pages	479-496
Number of pages	18
ISBN (Electronic)	9780128110225
ISBN (Print)	9780128134375
DOIs	https://doi.org/10.1016/B978-0-12-811022-5.00026-7
State	Published - Jan 1 2018

Keywords

Cancer biomarker
GWAS
MicroRNA
Noncoding RNA
SNPs

ASJC Scopus subject areas

Medicine(all)
Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.1016/B978-0-12-811022-5.00026-7

Cite this

@inbook{f415da9cab3c41ee9ad7cb8e23a37ff2,

title = "Noncoding RNAs as a Cause of Cancer",

abstract = "Noncoding RNAs (ncRNAs) are emerging as key regulators of tumorigenesis that control cancer-associated gene expression through microRNA-induced mRNA degradation or long ncRNA-mediated chromatin modification. They have been identified as highly promising cancer biomarkers through recent genome-wide association analysis, e.g., on single-nucleotide polymorphisms. This chapter will focus on the possible roles of ncRNA in causing cancer and review examples that also highlight the potential application of ncRNAs as diagnostic and prognostic biomarkers for cancer stratification and as therapeutic targets and agents for cancer treatment.",

keywords = "Cancer biomarker, GWAS, MicroRNA, Noncoding RNA, SNPs",

author = "Juan Cui",

year = "2018",

month = jan,

day = "1",

doi = "10.1016/B978-0-12-811022-5.00026-7",

language = "English (US)",

isbn = "9780128134375",

pages = "479--496",

booktitle = "Cancer and Noncoding RNAs",

publisher = "Elsevier",

}

TY - CHAP

T1 - Noncoding RNAs as a Cause of Cancer

AU - Cui, Juan

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Noncoding RNAs (ncRNAs) are emerging as key regulators of tumorigenesis that control cancer-associated gene expression through microRNA-induced mRNA degradation or long ncRNA-mediated chromatin modification. They have been identified as highly promising cancer biomarkers through recent genome-wide association analysis, e.g., on single-nucleotide polymorphisms. This chapter will focus on the possible roles of ncRNA in causing cancer and review examples that also highlight the potential application of ncRNAs as diagnostic and prognostic biomarkers for cancer stratification and as therapeutic targets and agents for cancer treatment.

AB - Noncoding RNAs (ncRNAs) are emerging as key regulators of tumorigenesis that control cancer-associated gene expression through microRNA-induced mRNA degradation or long ncRNA-mediated chromatin modification. They have been identified as highly promising cancer biomarkers through recent genome-wide association analysis, e.g., on single-nucleotide polymorphisms. This chapter will focus on the possible roles of ncRNA in causing cancer and review examples that also highlight the potential application of ncRNAs as diagnostic and prognostic biomarkers for cancer stratification and as therapeutic targets and agents for cancer treatment.

KW - Cancer biomarker

KW - GWAS

KW - MicroRNA

KW - Noncoding RNA

KW - SNPs

UR - http://www.scopus.com/inward/record.url?scp=85090938803&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85090938803&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-811022-5.00026-7

DO - 10.1016/B978-0-12-811022-5.00026-7

M3 - Chapter

AN - SCOPUS:85090938803

SN - 9780128134375

SP - 479

EP - 496

BT - Cancer and Noncoding RNAs

PB - Elsevier

ER -

Noncoding RNAs as a Cause of Cancer

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this