Noncoding RNAs as a Cause of Cancer

Juan Cui

doi:10.1016/B978-0-12-811022-5.00026-7

Noncoding RNAs as a Cause of Cancer

Juan Cui

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Noncoding RNAs (ncRNAs) are emerging as key regulators of tumorigenesis that control cancer-associated gene expression through microRNA-induced mRNA degradation or long ncRNA-mediated chromatin modification. They have been identified as highly promising cancer biomarkers through recent genome-wide association analysis, e.g., on single-nucleotide polymorphisms. This chapter will focus on the possible roles of ncRNA in causing cancer and review examples that also highlight the potential application of ncRNAs as diagnostic and prognostic biomarkers for cancer stratification and as therapeutic targets and agents for cancer treatment.

Original language	English (US)
Title of host publication	Cancer and Noncoding RNAs
Publisher	Elsevier
Pages	479-496
Number of pages	18
ISBN (Electronic)	9780128110225
ISBN (Print)	9780128134375
DOIs	https://doi.org/10.1016/B978-0-12-811022-5.00026-7
State	Published - Jan 1 2018

Keywords

Cancer biomarker
GWAS
MicroRNA
Noncoding RNA
SNPs

ASJC Scopus subject areas

General Medicine
General Biochemistry, Genetics and Molecular Biology

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10.1016/B978-0-12-811022-5.00026-7

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AB - Noncoding RNAs (ncRNAs) are emerging as key regulators of tumorigenesis that control cancer-associated gene expression through microRNA-induced mRNA degradation or long ncRNA-mediated chromatin modification. They have been identified as highly promising cancer biomarkers through recent genome-wide association analysis, e.g., on single-nucleotide polymorphisms. This chapter will focus on the possible roles of ncRNA in causing cancer and review examples that also highlight the potential application of ncRNAs as diagnostic and prognostic biomarkers for cancer stratification and as therapeutic targets and agents for cancer treatment.

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KW - GWAS

KW - MicroRNA

KW - Noncoding RNA

KW - SNPs

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BT - Cancer and Noncoding RNAs

PB - Elsevier

ER -

Noncoding RNAs as a Cause of Cancer

Abstract

Keywords

ASJC Scopus subject areas

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