Abstract
Noncoding RNAs (ncRNAs) are emerging as key regulators of tumorigenesis that control cancer-associated gene expression through microRNA-induced mRNA degradation or long ncRNA-mediated chromatin modification. They have been identified as highly promising cancer biomarkers through recent genome-wide association analysis, e.g., on single-nucleotide polymorphisms. This chapter will focus on the possible roles of ncRNA in causing cancer and review examples that also highlight the potential application of ncRNAs as diagnostic and prognostic biomarkers for cancer stratification and as therapeutic targets and agents for cancer treatment.
Original language | English (US) |
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Title of host publication | Cancer and Noncoding RNAs |
Publisher | Elsevier |
Pages | 479-496 |
Number of pages | 18 |
ISBN (Electronic) | 9780128110225 |
ISBN (Print) | 9780128134375 |
DOIs | |
State | Published - Jan 1 2018 |
Keywords
- Cancer biomarker
- GWAS
- MicroRNA
- Noncoding RNA
- SNPs
ASJC Scopus subject areas
- Medicine(all)
- Biochemistry, Genetics and Molecular Biology(all)