Noninvasive localization of epileptogenic zones with ictal high-frequency neuromagnetic signals: Case report

Jing Xiang, Yingying Wang, Yangmei Chen, Yang Liu, Rupesh Kotecha, Xiaolin Huo, Douglas F. Rose, Hisako Fujiwara, Nat Hemasilpin, Ki Lee, Francesco T. Mangano, Blaise Jones, Ton DeGrauw

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

Object. Recent reports suggest that high-frequency epileptic activity is highly localized to epileptogenic zones. The goal of the present study was to investigate the potential usefulness of noninvasive localization of high-frequency epileptic activity for epilepsy surgery. Methods. Data obtained in 4 patients, who had seizures during routine magnetoencephalography (MEG) tests, were retrospectively studied. The MEG data were digitized at 4000 Hz, and 3D MR images were obtained. The magnetic sources were volumetrically localized with wavelet-based beamformer. The MEG results were subsequently compared with clinical data. Results. The 4 patients had 1-4 high-frequency neuromagnetic components (110-910 Hz) in ictal and interictal activities. The loci of high-frequency activities were concordant with intracranial recordings therein 3 patients, who underwent presurgical evaluation. The loci of high-frequency ictal activities were in line with semiology and neuroimaging in all 4 of the patients. High-frequency epileptic activity was highly localized to the epileptogenic zones. Conclusions. High-frequency epileptic activity can be volumetrically localized with MEG. Source analysis of high-frequency neuromagnetic signals has the potential to determine epileptogenic zones noninvasively and preoperatively for epilepsy surgery.

Original languageEnglish (US)
Pages (from-to)113-122
Number of pages10
JournalJournal of Neurosurgery: Pediatrics
Volume5
Issue number1
DOIs
StatePublished - Jan 2010

Keywords

  • Childhood epilepsy
  • High-frequency oscillation
  • Magnetoencephalography
  • Ripple ictal activity

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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    Xiang, J., Wang, Y., Chen, Y., Liu, Y., Kotecha, R., Huo, X., Rose, D. F., Fujiwara, H., Hemasilpin, N., Lee, K., Mangano, F. T., Jones, B., & DeGrauw, T. (2010). Noninvasive localization of epileptogenic zones with ictal high-frequency neuromagnetic signals: Case report. Journal of Neurosurgery: Pediatrics, 5(1), 113-122. https://doi.org/10.3171/2009.8.PEDS09345