Novel drug delivery systems based on the complexes of block ionomers and surfactants of opposite charge

Tatiana K. Bronich, Andrew Nehls, Adi Eisenberg, Victor A. Kabanov, Alexander V. Kabanov

Research output: Contribution to journalArticle

83 Scopus citations

Abstract

In this paper we have evaluated a novel family of polymer-surfactant complexes formed between block ionomers and oppositely charged surfactants. Complexes between cationic copolymer poly(ethylene oxide)-g-polyethyleneimine (PEO-g-PEI) and sodium salt of oleic acid, natural nontoxic surfactant, are prepared and characterized. These systems self-assemble in aqueous solutions into particles with average size of 50-60 nm, which can solubilize hydrophobic dyes (Yellow OB) and drug molecules (paclitaxel). The use of the biologically active surfactants as components of block ionomer complexes is demonstrated for the complexes from PEO-g-PEI and all-trans-retinoic acid. Binding of relatively soluble drugs with block ionomers is illustrated using PEO-b-poly(sodium methacrylate) and doxorubicin. Overall these studies suggest that block ionomer complexes can be used to prepare a variety of soluble and stable formulations of biologically active compounds, and have potential application as drug delivery systems.

Original languageEnglish (US)
Pages (from-to)243-251
Number of pages9
JournalColloids and Surfaces B: Biointerfaces
Volume16
Issue number1-4
DOIs
StatePublished - Nov 1 1999

Keywords

  • All-trans- retinoic acid
  • Block copolymers
  • Doxorubicin
  • Oleic acid
  • Paclitaxel
  • Polymer-surfactant complexes

ASJC Scopus subject areas

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

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