Novel drug delivery systems: nanogel networks

Serguei Vinogradov, Elena Batrakova, Alexander V. Kabanov

Research output: Contribution to journalConference articlepeer-review

Abstract

A novel SODN delivery system was developed based on hydrogel particles with effective diameters from ca. 20 to 220 nm. Small particles of loaded nanogel readily entered cells. Further, antisense SODNs incorporated in nanogel revealed the ability to reach targets in the cell and efficiently suppressed gene expression in a sequence-specific fashion. Using the cell models of intestinal and blood brain barrier, the potential of nanogels for oral and brain delivery of SODN was demonstrated.

Original languageEnglish (US)
Pages (from-to)1641-1642
Number of pages2
JournalAmerican Chemical Society, Polymer Preprints, Division of Polymer Chemistry
Volume41
Issue number2
StatePublished - Aug 2000
EventWashington,DC. Meeting - Washington, DC, USA
Duration: Aug 20 2000Aug 24 2000

ASJC Scopus subject areas

  • Polymers and Plastics

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