Abstract
A novel SODN delivery system was developed based on hydrogel particles with effective diameters from ca. 20 to 220 nm. Small particles of loaded nanogel readily entered cells. Further, antisense SODNs incorporated in nanogel revealed the ability to reach targets in the cell and efficiently suppressed gene expression in a sequence-specific fashion. Using the cell models of intestinal and blood brain barrier, the potential of nanogels for oral and brain delivery of SODN was demonstrated.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1641-1642 |
| Number of pages | 2 |
| Journal | American Chemical Society, Polymer Preprints, Division of Polymer Chemistry |
| Volume | 41 |
| Issue number | 2 |
| State | Published - Aug 2000 |
| Externally published | Yes |
| Event | Washington,DC. Meeting - Washington, DC, USA Duration: Aug 20 2000 → Aug 24 2000 |
ASJC Scopus subject areas
- Polymers and Plastics