Novel inhibitors of the renal inward rectifier potassium channel of the mosquito vector Aedes aegypti

Viktoriya Mashinson, Corey R. Hopkins

Research output: Contribution to journalReview articlepeer-review

Abstract

The mosquito continues to be the most lethal animal to humans due to the devastating diseases that it carries and transmits. Controlling mosquito-borne diseases relies heavily on vector management using neurotoxic insecticides with limited modes of action. This has led to the emergence of resistance to pyrethroids and other neurotoxic insecticides in mosquitoes, which has reduced the efficacy of chemical control agents. Moreover, many neurotoxic insecticides are not selective for mosquitoes and negatively impact beneficial insects such as honeybees. Developing new mosquitocides with novel mechanisms of action is a clear unmet medical need; this review covers the efforts made toward this end by targeting the renal inward rectifier potassium channel (Kir) of the mosquito.

Original languageEnglish (US)
Pages (from-to)2015-2025
Number of pages11
JournalFuture Medicinal Chemistry
Volume13
Issue number22
DOIs
StatePublished - Nov 2021

Keywords

  • Ion channel
  • Kir channel
  • Mosquito vector
  • Mosquitocide
  • Zika virus

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

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