Novel pyrazinone inhibitors of mast cell tryptase: Synthesis and SAR evaluation

Corey Hopkins, Kent Neuenschwander, Anthony Scotese, Sharon Jackson, Thaddeus Nieduzak, Henry Pauls, Guyan Liang, Keith Sides, Dona Cramer, Jennifer Cairns, Sebastien Maignan, Magali Mathieu

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


In this manuscript, the synthesis and SAR evaluation of a novel pyrazinone class of tryptase inhibitors is described. Chemical optimization of the P1 and P4 groups led to the identification of 7p (K i = 93 nM) as a potent inhibitor of mast cell tryptase.

Original languageEnglish (US)
Pages (from-to)4819-4823
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Issue number19
StatePublished - Oct 4 2004
Externally publishedYes


  • Mast cell tryptase
  • Pyrazinone
  • SAR

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Novel pyrazinone inhibitors of mast cell tryptase: Synthesis and SAR evaluation'. Together they form a unique fingerprint.

Cite this