Novel reporter mouse models useful for evaluating in vivo gene editing and for optimization of methods of delivering genome editing tools

Hiromi Miura, Jurai Imafuku, Aki Kurosaki, Masahiro Sato, Yongjie Ma, Guisheng Zhang, Akiko Mizutani, Kenya Kamimura, Channabasavaiah B. Gurumurthy, Dexi Liu, Masato Ohtsuka

Research output: Contribution to journalArticlepeer-review

Abstract

CRISPR-Cas is a revolutionary genome-editing technology that is making big impacts in biomedical research and gene therapy. Miura and colleagues developed reporter mice that can emit green fluorescence only in the edited cells or tissues and showed their utility as the much-needed in vivo tools for evaluating CRISPR-Cas technology.

Original languageEnglish (US)
Pages (from-to)325-336
Number of pages12
JournalMolecular Therapy - Nucleic Acids
Volume24
DOIs
StatePublished - Jun 4 2021

Keywords

  • CRISPR
  • EGFP
  • gene therapy
  • genome editing efficiency
  • hydrodynamic gene delivery
  • in vivo gene editing
  • transgenic mice

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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