Abstract
CRISPR-Cas is a revolutionary genome-editing technology that is making big impacts in biomedical research and gene therapy. Miura and colleagues developed reporter mice that can emit green fluorescence only in the edited cells or tissues and showed their utility as the much-needed in vivo tools for evaluating CRISPR-Cas technology.
Original language | English (US) |
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Pages (from-to) | 325-336 |
Number of pages | 12 |
Journal | Molecular Therapy Nucleic Acids |
Volume | 24 |
DOIs | |
State | Published - Jun 4 2021 |
Keywords
- CRISPR
- EGFP
- gene therapy
- genome editing efficiency
- hydrodynamic gene delivery
- in vivo gene editing
- transgenic mice
ASJC Scopus subject areas
- Molecular Medicine
- Drug Discovery