4 Scopus citations


The human carcinogen diethylstilbestrol (DES) is metabolized into 3′-hydroxydiethylstilbestrol (3′-OH-DES) (1). Chemical oxidation of the catechol metabolites with silver oxide in CH2Cl2 affords a novel spiro-quinone (3) in quantitative yield. Protection of the phenolic OH group followed by oxidation gives 4″-OCH3-DES- 3′,4′-Q (5) in excellent yield.

Original languageEnglish (US)
Pages (from-to)4449-4451
Number of pages3
JournalTetrahedron Letters
Issue number26
StatePublished - Jun 27 2005


  • Catechol estrogen
  • Depurinating adducts
  • Diethylstilbestrol
  • Oxidation
  • spiro-Quinone

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Novel spiro-quinone formation from 3′-hydroxydiethylstilbestrol after oxidation with silver oxide'. Together they form a unique fingerprint.

Cite this