Novel strategies to delineate matrix metalloproteinase (MMP)-substrate relationships and identify targets to block MMP activity

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

Adverse extracellular matrix (ECM) remodeling contributes to fibrotic disorders in the kidney, lung, and heart. Matrix metalloproteinases (MMPs) are key enzymes regulating ECM turnover, and MMP inhibition attenuates remodeling. Recent technological developments allow MMP-substrate relationships to be identified and explored as novel therapeutic targets. This review summarizes current and novel strategies to block MMP activity.

Original languageEnglish (US)
Pages (from-to)1243-1248
Number of pages6
JournalMini-Reviews in Medicinal Chemistry
Volume6
Issue number11
DOIs
StatePublished - Nov 2006

Keywords

  • Extracellular matrix
  • Fibrosis
  • MMP inhibitors
  • Matrix metalloproteinases
  • Mechanism-based inhibition
  • Proteomics
  • Remodeling

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Cancer Research

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