Novel 19F MRS/I nanoprobe based on pH-responsive PEGylated nanogel: pH-dependent 19F magnetic resonance studies

Motoi Oishi, Shogo Sumitani, Tatiana K. Bronich, Alexander V. Kabanov, Michael D. Boska, Yukio Nagasaki

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

The pH-responsive PEGylated nanogels composed of the cross-linked poly[2-(N,N-diethylamino)ethyl methacrylatej-copoly(2,2,2-trifluoroethyl methacrylate) gel core showed a remarkable on-off regulation of 19F magnetic resonance signal intensity (T 2 values) as well as signal-to-noise ratios in response to extracellular pH 6.5 of tumor environment under 19F magnetic resonance spectroscopic imaging (MRS/I), demonstrating the utility of the PEGylated nanogels as solid tumor-specific 19F MPJ/S nanoprobes.

Original languageEnglish (US)
Pages (from-to)128-129
Number of pages2
JournalChemistry Letters
Volume38
Issue number2
DOIs
StatePublished - 2009

ASJC Scopus subject areas

  • Chemistry(all)

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