Novel 19F MRS/I nanoprobe based on pH-responsive PEGylated nanogel: pH-dependent 19F magnetic resonance studies

Motoi Oishi; Shogo Sumitani; Tatiana K. Bronich; Alexander V. Kabanov; Michael D. Boska; Yukio Nagasaki

doi:10.1246/cl.2009.128

Novel ¹⁹F MRS/I nanoprobe based on pH-responsive PEGylated nanogel: pH-dependent ¹⁹F magnetic resonance studies

Motoi Oishi, Shogo Sumitani, Tatiana K. Bronich, Alexander V. Kabanov, Michael D. Boska, Yukio Nagasaki

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

The pH-responsive PEGylated nanogels composed of the cross-linked poly[2-(N,N-diethylamino)ethyl methacrylatej-copoly(2,2,2-trifluoroethyl methacrylate) gel core showed a remarkable on-off regulation of ¹⁹F magnetic resonance signal intensity (T ₂ values) as well as signal-to-noise ratios in response to extracellular pH 6.5 of tumor environment under ¹⁹F magnetic resonance spectroscopic imaging (MRS/I), demonstrating the utility of the PEGylated nanogels as solid tumor-specific ¹⁹F MPJ/S nanoprobes.

Original language	English (US)
Pages (from-to)	128-129
Number of pages	2
Journal	Chemistry Letters
Volume	38
Issue number	2
DOIs	https://doi.org/10.1246/cl.2009.128
State	Published - 2009

ASJC Scopus subject areas

General Chemistry

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title = "Novel 19F MRS/I nanoprobe based on pH-responsive PEGylated nanogel: pH-dependent 19F magnetic resonance studies",

abstract = "The pH-responsive PEGylated nanogels composed of the cross-linked poly[2-(N,N-diethylamino)ethyl methacrylatej-copoly(2,2,2-trifluoroethyl methacrylate) gel core showed a remarkable on-off regulation of 19F magnetic resonance signal intensity (T 2 values) as well as signal-to-noise ratios in response to extracellular pH 6.5 of tumor environment under 19F magnetic resonance spectroscopic imaging (MRS/I), demonstrating the utility of the PEGylated nanogels as solid tumor-specific 19F MPJ/S nanoprobes.",

author = "Motoi Oishi and Shogo Sumitani and Bronich, {Tatiana K.} and Kabanov, {Alexander V.} and Boska, {Michael D.} and Yukio Nagasaki",

year = "2009",

doi = "10.1246/cl.2009.128",

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T1 - Novel 19F MRS/I nanoprobe based on pH-responsive PEGylated nanogel

T2 - pH-dependent 19F magnetic resonance studies

AU - Oishi, Motoi

AU - Sumitani, Shogo

AU - Bronich, Tatiana K.

AU - Kabanov, Alexander V.

AU - Boska, Michael D.

AU - Nagasaki, Yukio

PY - 2009

Y1 - 2009

N2 - The pH-responsive PEGylated nanogels composed of the cross-linked poly[2-(N,N-diethylamino)ethyl methacrylatej-copoly(2,2,2-trifluoroethyl methacrylate) gel core showed a remarkable on-off regulation of 19F magnetic resonance signal intensity (T 2 values) as well as signal-to-noise ratios in response to extracellular pH 6.5 of tumor environment under 19F magnetic resonance spectroscopic imaging (MRS/I), demonstrating the utility of the PEGylated nanogels as solid tumor-specific 19F MPJ/S nanoprobes.

AB - The pH-responsive PEGylated nanogels composed of the cross-linked poly[2-(N,N-diethylamino)ethyl methacrylatej-copoly(2,2,2-trifluoroethyl methacrylate) gel core showed a remarkable on-off regulation of 19F magnetic resonance signal intensity (T 2 values) as well as signal-to-noise ratios in response to extracellular pH 6.5 of tumor environment under 19F magnetic resonance spectroscopic imaging (MRS/I), demonstrating the utility of the PEGylated nanogels as solid tumor-specific 19F MPJ/S nanoprobes.

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JF - Chemistry Letters

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Novel ¹⁹F MRS/I nanoprobe based on pH-responsive PEGylated nanogel: pH-dependent ¹⁹F magnetic resonance studies

Abstract

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