Abstract
Importance of the field: Dental caries is one of the most common preventable childhood diseases; people are susceptible to this ailment throughout their lifetime. In the US, 90% of late adolescents and young adults have dental caries, while 94% of all dentate adults had evidence of treated or untreated coronal caries. Dental caries is often not self-limiting and without proper care can progress until the tooth is destroyed. Areas covered in this review: In this paper, the etiology of dental caries is briefly introduced. It is followed by a thorough review of patents and literatures on the recent development of various novel technologies for the prevention and treatment of dental caries. What the reader will gain: Recent advances in anti-plaque agents, including chemoprophylactic agents, antimicrobial peptides, vaccines, probiotics/replacement therapy and sugar substitutes, and remineralization agents including fluorides and casein phosphopeptides are analyzed. Take home massage: Both the discovery of new anti-caries agents and the development of dentotropic delivery systems will be the future focus of this research field.
Original language | English (US) |
---|---|
Pages (from-to) | 681-694 |
Number of pages | 14 |
Journal | Expert Opinion on Therapeutic Patents |
Volume | 20 |
Issue number | 5 |
DOIs | |
State | Published - May 2010 |
Keywords
- Antimicrobial
- Dental caries
- Drug delivery
- Fluoride therapy
- Sugar substitute
ASJC Scopus subject areas
- Pharmacology
- Drug Discovery