Novel technologies for the prevention and treatment of dental caries: A patent survey

Fu Chen, Dong Wang

Research output: Contribution to journalReview articlepeer-review

90 Scopus citations


Importance of the field: Dental caries is one of the most common preventable childhood diseases; people are susceptible to this ailment throughout their lifetime. In the US, 90% of late adolescents and young adults have dental caries, while 94% of all dentate adults had evidence of treated or untreated coronal caries. Dental caries is often not self-limiting and without proper care can progress until the tooth is destroyed. Areas covered in this review: In this paper, the etiology of dental caries is briefly introduced. It is followed by a thorough review of patents and literatures on the recent development of various novel technologies for the prevention and treatment of dental caries. What the reader will gain: Recent advances in anti-plaque agents, including chemoprophylactic agents, antimicrobial peptides, vaccines, probiotics/replacement therapy and sugar substitutes, and remineralization agents including fluorides and casein phosphopeptides are analyzed. Take home massage: Both the discovery of new anti-caries agents and the development of dentotropic delivery systems will be the future focus of this research field.

Original languageEnglish (US)
Pages (from-to)681-694
Number of pages14
JournalExpert Opinion on Therapeutic Patents
Issue number5
StatePublished - May 2010


  • Antimicrobial
  • Dental caries
  • Drug delivery
  • Fluoride therapy
  • Sugar substitute

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery


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