TY - JOUR
T1 - Novelty reward as a measure of anhedonia
AU - Bevins, Rick A.
AU - Besheer, Joyce
N1 - Funding Information:
Some of the research described in this report was supported by USPHS grants MH57240, DA11893, and DA06092. We thank K.S. Bevins and M.I. Palmatier for their thoughtful comments on an earlier version of this manuscript.
PY - 2005
Y1 - 2005
N2 - A decrease in sensitivity to pleasurable stimuli, anhedonia, is a major symptom of depression in humans. Several animal models have been developed to simulate this symptom (e.g. drug withdrawal, learned helplessness) using reward-sensitive procedures such as intracranial self-stimulation and progressive ratio responding as a measure of reward function. Recently, we introduced the use of another procedure, novel-object place conditioning in rats, to measure reward function in an associative learning situation. Withdrawal from chronic nicotine blocked a place preference conditioned by access to novel objects. This blockade was not due to impairment of object interaction, general activity, novelty detection, environmental familiarization, or expression of learning. Consequently, nicotine withdrawal directly reduced the rewarding properties of novelty. It is proposed that the novel-object place conditioning procedure could be usefully extended to other experimental situations and to genetically altered mice, so as to better understand the processes underlying changes in reward function.
AB - A decrease in sensitivity to pleasurable stimuli, anhedonia, is a major symptom of depression in humans. Several animal models have been developed to simulate this symptom (e.g. drug withdrawal, learned helplessness) using reward-sensitive procedures such as intracranial self-stimulation and progressive ratio responding as a measure of reward function. Recently, we introduced the use of another procedure, novel-object place conditioning in rats, to measure reward function in an associative learning situation. Withdrawal from chronic nicotine blocked a place preference conditioned by access to novel objects. This blockade was not due to impairment of object interaction, general activity, novelty detection, environmental familiarization, or expression of learning. Consequently, nicotine withdrawal directly reduced the rewarding properties of novelty. It is proposed that the novel-object place conditioning procedure could be usefully extended to other experimental situations and to genetically altered mice, so as to better understand the processes underlying changes in reward function.
KW - Conditioned place preference
KW - Depression
KW - Drug withdrawal
KW - Nicotine
KW - Object recognition
KW - Pavlovian conditioning
KW - Reward learning
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U2 - 10.1016/j.neubiorev.2005.03.013
DO - 10.1016/j.neubiorev.2005.03.013
M3 - Review article
C2 - 15876456
AN - SCOPUS:19944368470
SN - 0149-7634
VL - 29
SP - 707
EP - 714
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
IS - 4-5
ER -