Nrf2-Keap1 in Cardiovascular Disease: Which Is the Cart and Which the Horse?

Neha Dhyani, Changhai Tian, Lie Gao, Tara L. Rudebush, Irving H. Zucker

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

High levels of oxidant stress in the form of reactive oxidant species are prevalent in the circulation and tissues in various types of cardiovascular disease including heart failure, hypertension, peripheral arterial disease, and stroke. Here we review the role of nuclear factor erythroid 2-related factor 2 (Nrf2), an important and widespread antioxidant and anti-inflammatory transcription factor that may contribute to the pathogenesis and maintenance of cardiovascular diseases. We review studies showing that downregulation of Nrf2 exacerbates heart failure, hypertension, and autonomic function. Finally, we discuss the potential for using Nrf2 modulation as a therapeutic strategy for cardiovascular diseases and autonomic dysfunction.

Original languageEnglish (US)
Pages (from-to)288-301
Number of pages14
JournalPhysiology
Volume39
Issue number5
DOIs
StatePublished - Sep 2024

Keywords

  • Nrf2
  • antioxidant proteins
  • heart failure
  • hypertension
  • oxidative stress

ASJC Scopus subject areas

  • Physiology

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