NSAIDs and Acetaminophen for Acute and Chronic Pain

Kimberley Haynes-Henson, Ryan Birkland, Madhuri Are

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Acetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs) combat fever and decrease both acute and chronic pain. Hippocrates, in the fifth century BC, wrote about the use of powdered willow bark for treating fever and pain. In modern times, the use of NSAIDs became commonplace with the production of acetyl salicylic acid or aspirin by Bayer in the early nineteenth century. (Brogan SE, Mandyam S, Odell DW. 19 - nonopioid analgesics. 2019:369–389 and Royston D. 45 – anticoagulation and anti-platelet therapy. 2019:883–4). Pharmacology and physiology for anesthesia: foundations and clinical application, sec ed. Hemmings H). Since then, the use of NSAIDs have exploded to the point that they are now one of the most commonly used classes of medications for both perioperative acute pain and chronic pain management.

Original languageEnglish (US)
Title of host publicationAnesthesiology In-Training Exam Review
Subtitle of host publicationRegional Anesthesia and Chronic Pain
PublisherSpringer International Publishing
Number of pages6
ISBN (Electronic)9783030872663
ISBN (Print)9783030872656
StatePublished - Jan 1 2022


  • Analgesia
  • COX inhibitors
  • COX-1
  • COX-2
  • Inflammatory cascade
  • Non-opioid analgesic
  • Prostacyclin
  • Prostaglandin
  • Thromboxane

ASJC Scopus subject areas

  • Medicine(all)


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