N5-Phosphonoacetyl-l-ornithine (PALO): A convenient synthesis and investigation of influence on regulation of amino acid biosynthetic genes in Saccharomyces cerevisiae

Brad Johnson, Rachel Steadman, Krista D. Patefield, Jeffrey J. Bunker, Audrey L. Atkin, Patrick Dussault

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

A scalable four-step synthesis of the ornithine transcarbamylase inhibitor N5-phosphonoacetyl-l-ornithine (PALO) is achieved through boroxazolidinone protection of ornithine. Investigations in the model organism Saccharomyces cerevisiae found that, in contrast to a previous report, PALO did not influence growth rate or expression of genes involved in arginine metabolism.

Original languageEnglish (US)
Pages (from-to)2351-2353
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume21
Issue number8
DOIs
StatePublished - Apr 15 2011

Keywords

  • Arginine biosynthesis
  • Ornithine transcarbamylase
  • PALO
  • Saccharomyces cerevisiae

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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