Nuclear translocation of spike mRNA and protein is a novel feature of SARS-CoV-2

Sarah Sattar, Juraj Kabat, Kailey Jerome, Friederike Feldmann, Kristina Bailey, Masfique Mehedi

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes severe pathophysiology in vulnerable older populations and appears to be highly pathogenic and more transmissible than other coronaviruses. The spike (S) protein appears to be a major pathogenic factor that contributes to the unique pathogenesis of SARS-CoV-2. Although the S protein is a surface transmembrane type 1 glycoprotein, it has been predicted to be translocated into the nucleus due to the novel nuclear localization signal (NLS) “PRRARSV,” which is absent from the S protein of other coronaviruses. Indeed, S proteins translocate into the nucleus in SARS-CoV-2-infected cells. S mRNAs also translocate into the nucleus. S mRNA colocalizes with S protein, aiding the nuclear translocation of S mRNA. While nuclear translocation of nucleoprotein (N) has been shown in many coronaviruses, the nuclear translocation of both S mRNA and S protein reveals a novel feature of SARS-CoV-2.

Original languageEnglish (US)
Article number1073789
JournalFrontiers in Microbiology
StatePublished - Jan 26 2023


  • mRNA
  • NLS
  • nuclear translocation
  • SARS-CoV-2
  • spike

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)


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