Nucleic-acid-based antiviral agents against positive single-stranded RNA viruses

Travis W. Lim, Ji Yuan, Zhen Liu, Dexin Qiu, Alhousseynou Sall, Decheng Yang

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Positive single-stranded RNA viruses constitute a broad and prevalent group of pathogens that threaten human health and life worldwide. While effective vaccines have been developed for some, such as poliovirus and hepatitis A, others such as coxsackievirus, severe acute respiratory syndrome coronavirus (SARS-CoV) and West Nile virus have no accredited drug treatments. Antisense technologies, which encompass small interfering RNA, antisense oligonucleotides, ribozymes and their chemically modified analogs, involve small sequence-specific nucleic-acid-based molecules that inhibit viral replication at the level of translation. Many antisense oligomers are proven antiviral agents in vitro. In this review, we provide an overview of the antiviral antisense field, highlighting specific studies of interest over the past several years, using our experience with coxsackievirus B3 as a reference point. Overall, both the challenges and successes of existing antisense therapies for positive single-stranded RNA viruses can be paralleled to those for other virus groups, and vice versa.

Original languageEnglish (US)
Pages (from-to)104-107
Number of pages4
JournalCurrent Opinion in Molecular Therapeutics
Volume8
Issue number2
StatePublished - Apr 2006
Externally publishedYes

Keywords

  • Antisense
  • Antiviral drug therapy
  • Coxsackievirus
  • Phosphorodiamidate morpholino oligomers (PMO)
  • Positive single-stranded RNA virus (+ssRNA virus)
  • Small interfering RNA (siRNA)

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Pharmacology
  • Drug Discovery
  • Genetics(clinical)

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