Nucleolar proteins and cancer: The roles of aurora a-interacting nucleolar proteins in mitosis and cancer

Jyoti Iyer, Saili Moghe, Manabu Furukawa, Ming Ying Tsai

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Nucleolar proteins have been in the limelight due to their involvement in multiple cellular processes other than their well-studied functions in maintaining the structural integrity of the nucleolus and ribosome synthesis. Many of these nucleolar proteins have now been shown to play roles in the processes of mitosis as well as tumorigenesis. In this book chapter, we have discussed the contribution of three such Aurora A-interacting nucleolar proteins: NuSAP, Arpc1b and Eg5, to mitosis and tumor progression. Importantly, we have also brought into light several unanswered questions pertaining to the function and regulation of these nucleolar proteins in both mitosis as well as cancer. Finally, we have attempted to reason why several nucleolar proteins have now been implicated as important players in mitosis.

Original languageEnglish (US)
Title of host publicationProteins of the Nucleolus: Regulation, Translocation, & Biomedical Functions
PublisherSpringer Netherlands
Pages323-342
Number of pages20
Volume9789400758186
ISBN (Electronic)9789400758186
ISBN (Print)9400758170, 9789400758179
DOIs
StatePublished - Sep 1 2013

Keywords

  • Arpc1b
  • Aurora A
  • Cancer
  • Eg5/mitotic kinesin 5/KIF11
  • NuSAP

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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