Nucleoside and nucleobase analog mutagens

Kazuo Negishi; Tadayashi Bessho; Hikoya Hayatsu

doi:10.1016/0165-1110(94)90016-7

Nucleoside and nucleobase analog mutagens

Kazuo Negishi, Tadayashi Bessho, Hikoya Hayatsu

Research output: Contribution to journal › Review article

18 Scopus citations

Abstract

Compounds with structures close to those of normal nucleosides or nucleobases may be incorporated into cells and then become constituent of their DNA. Proliferation of such cells could yield mutants. In this article, the current status of studies on such nucleoside and nucleobase analogs is described. Base mispairing mechanisms for these analogs are discussed in light of recent biochemical and biophysical findings.

Original language	English (US)
Pages (from-to)	227-238
Number of pages	12
Journal	Mutation Research/Reviews in Genetic Toxicology
Volume	318
Issue number	3
DOIs	https://doi.org/10.1016/0165-1110(94)90016-7
State	Published - Dec 1994

ASJC Scopus subject areas

Toxicology
Genetics

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Negishi, K., Bessho, T., & Hayatsu, H. (1994). Nucleoside and nucleobase analog mutagens. Mutation Research/Reviews in Genetic Toxicology, 318(3), 227-238. https://doi.org/10.1016/0165-1110(94)90016-7

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abstract = "Compounds with structures close to those of normal nucleosides or nucleobases may be incorporated into cells and then become constituent of their DNA. Proliferation of such cells could yield mutants. In this article, the current status of studies on such nucleoside and nucleobase analogs is described. Base mispairing mechanisms for these analogs are discussed in light of recent biochemical and biophysical findings.",

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