Nucleoside and nucleobase analog mutagens

Kazuo Negishi; Tadayashi Bessho; Hikoya Hayatsu

doi:10.1016/0165-1110(94)90016-7

Nucleoside and nucleobase analog mutagens

Kazuo Negishi, Tadayashi Bessho, Hikoya Hayatsu

Research output: Contribution to journal › Review article › peer-review

18 Scopus citations

Abstract

Compounds with structures close to those of normal nucleosides or nucleobases may be incorporated into cells and then become constituent of their DNA. Proliferation of such cells could yield mutants. In this article, the current status of studies on such nucleoside and nucleobase analogs is described. Base mispairing mechanisms for these analogs are discussed in light of recent biochemical and biophysical findings.

Original language	English (US)
Pages (from-to)	227-238
Number of pages	12
Journal	Mutation Research/Reviews in Genetic Toxicology
Volume	318
Issue number	3
DOIs	https://doi.org/10.1016/0165-1110(94)90016-7
State	Published - Dec 1994
Externally published	Yes

ASJC Scopus subject areas

Toxicology
Genetics

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title = "Nucleoside and nucleobase analog mutagens",

abstract = "Compounds with structures close to those of normal nucleosides or nucleobases may be incorporated into cells and then become constituent of their DNA. Proliferation of such cells could yield mutants. In this article, the current status of studies on such nucleoside and nucleobase analogs is described. Base mispairing mechanisms for these analogs are discussed in light of recent biochemical and biophysical findings.",

author = "Kazuo Negishi and Tadayashi Bessho and Hikoya Hayatsu",

note = "Funding Information: We thank Dr. Michael D. Waters (United States Environmental Protection Agency) for his kind offer of the mutagenicity data from his Genetic Activity Profile database. Financial support for our research on the analog mutagenesis was provided by a Grant-in-Aid from the Ministry of Education, Science and Culture, Japan.",

year = "1994",

month = dec,

doi = "10.1016/0165-1110(94)90016-7",

language = "English (US)",

volume = "318",

pages = "227--238",

journal = "Mutation Research - Reviews in Genetic Toxicology",

issn = "0165-1110",

publisher = "Elsevier BV",

number = "3",

}

TY - JOUR

T1 - Nucleoside and nucleobase analog mutagens

AU - Negishi, Kazuo

AU - Bessho, Tadayashi

AU - Hayatsu, Hikoya

N1 - Funding Information: We thank Dr. Michael D. Waters (United States Environmental Protection Agency) for his kind offer of the mutagenicity data from his Genetic Activity Profile database. Financial support for our research on the analog mutagenesis was provided by a Grant-in-Aid from the Ministry of Education, Science and Culture, Japan.

PY - 1994/12

Y1 - 1994/12

N2 - Compounds with structures close to those of normal nucleosides or nucleobases may be incorporated into cells and then become constituent of their DNA. Proliferation of such cells could yield mutants. In this article, the current status of studies on such nucleoside and nucleobase analogs is described. Base mispairing mechanisms for these analogs are discussed in light of recent biochemical and biophysical findings.

AB - Compounds with structures close to those of normal nucleosides or nucleobases may be incorporated into cells and then become constituent of their DNA. Proliferation of such cells could yield mutants. In this article, the current status of studies on such nucleoside and nucleobase analogs is described. Base mispairing mechanisms for these analogs are discussed in light of recent biochemical and biophysical findings.

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U2 - 10.1016/0165-1110(94)90016-7

DO - 10.1016/0165-1110(94)90016-7

M3 - Review article

C2 - 7527486

AN - SCOPUS:13844323892

VL - 318

SP - 227

EP - 238

JO - Mutation Research - Reviews in Genetic Toxicology

JF - Mutation Research - Reviews in Genetic Toxicology

SN - 0165-1110

IS - 3

ER -

Nucleoside and nucleobase analog mutagens

Abstract

ASJC Scopus subject areas

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