O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3

Xinghui Li; Wei Gong; Hao Wang; Tianliang Li; Kuldeep S. Attri; Robert E. Lewis; Andre C. Kalil; Fatema Bhinderwala; Robert Powers; Guowei Yin; Laura E. Herring; John M. Asara; Yu L. Lei; Xiaoyong Yang; Diego A. Rodriguez; Mao Yang; Douglas R. Green; Pankaj K. Singh; Haitao Wen

doi:10.1016/j.immuni.2019.01.007

O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3

Xinghui Li, Wei Gong, Hao Wang, Tianliang Li, Kuldeep S. Attri, Robert E. Lewis, Andre C. Kalil, Fatema Bhinderwala, Robert Powers, Guowei Yin, Laura E. Herring, John M. Asara, Yu L. Lei, Xiaoyong Yang, Diego A. Rodriguez, Mao Yang, Douglas R. Green, Pankaj K. Singh, Haitao Wen

Research output: Contribution to journal › Article

13 Scopus citations

Abstract

The role of individual glucose metabolic pathways in innate immunity remains largely unknown. Li et al. demonstrate that attenuated O-linked β-N-acetylglucosamine (O-GlcNAc) signaling enhances TLR-induced innate immune response and necroptosis. Mechanistically, O-GlcNAcylation of the kinase RIPK3 blocks RHIM-domain-mediated protein interaction and downstream signaling activation.

Original language	English (US)
Pages (from-to)	576-590.e6
Journal	Immunity
Volume	50
Issue number	3
DOIs	https://doi.org/10.1016/j.immuni.2019.01.007
State	Published - Mar 19 2019

Keywords

HBP
O-GlcNAc
OGT
RIPK3
inflammation
necroptosis

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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Li, X., Gong, W., Wang, H., Li, T., Attri, K. S., Lewis, R. E., Kalil, A. C., Bhinderwala, F., Powers, R., Yin, G., Herring, L. E., Asara, J. M., Lei, Y. L., Yang, X., Rodriguez, D. A., Yang, M., Green, D. R., Singh, P. K., & Wen, H. (2019). O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3. Immunity, 50(3), 576-590.e6. https://doi.org/10.1016/j.immuni.2019.01.007

O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3. / Li, Xinghui; Gong, Wei; Wang, Hao; Li, Tianliang; Attri, Kuldeep S.; Lewis, Robert E.; Kalil, Andre C.; Bhinderwala, Fatema; Powers, Robert; Yin, Guowei; Herring, Laura E.; Asara, John M.; Lei, Yu L.; Yang, Xiaoyong; Rodriguez, Diego A.; Yang, Mao; Green, Douglas R.; Singh, Pankaj K.; Wen, Haitao.

In: Immunity, Vol. 50, No. 3, 19.03.2019, p. 576-590.e6.

Research output: Contribution to journal › Article

Li, X, Gong, W, Wang, H, Li, T, Attri, KS, Lewis, RE , Kalil, AC, Bhinderwala, F, Powers, R, Yin, G, Herring, LE, Asara, JM, Lei, YL, Yang, X, Rodriguez, DA, Yang, M, Green, DR, Singh, PK & Wen, H 2019, 'O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3', Immunity, vol. 50, no. 3, pp. 576-590.e6. https://doi.org/10.1016/j.immuni.2019.01.007

Li, Xinghui ; Gong, Wei ; Wang, Hao ; Li, Tianliang ; Attri, Kuldeep S. ; Lewis, Robert E. ; Kalil, Andre C. ; Bhinderwala, Fatema ; Powers, Robert ; Yin, Guowei ; Herring, Laura E. ; Asara, John M. ; Lei, Yu L. ; Yang, Xiaoyong ; Rodriguez, Diego A. ; Yang, Mao ; Green, Douglas R. ; Singh, Pankaj K. ; Wen, Haitao. / O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3. In: Immunity. 2019 ; Vol. 50, No. 3. pp. 576-590.e6.

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abstract = "The role of individual glucose metabolic pathways in innate immunity remains largely unknown. Li et al. demonstrate that attenuated O-linked β-N-acetylglucosamine (O-GlcNAc) signaling enhances TLR-induced innate immune response and necroptosis. Mechanistically, O-GlcNAcylation of the kinase RIPK3 blocks RHIM-domain-mediated protein interaction and downstream signaling activation.",

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