O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3

Xinghui Li, Wei Gong, Hao Wang, Tianliang Li, Kuldeep S. Attri, Robert E. Lewis, Andre C. Kalil, Fatema Bhinderwala, Robert Powers, Guowei Yin, Laura E. Herring, John M. Asara, Yu L. Lei, Xiaoyong Yang, Diego A. Rodriguez, Mao Yang, Douglas R. Green, Pankaj K. Singh, Haitao Wen

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

The role of individual glucose metabolic pathways in innate immunity remains largely unknown. Li et al. demonstrate that attenuated O-linked β-N-acetylglucosamine (O-GlcNAc) signaling enhances TLR-induced innate immune response and necroptosis. Mechanistically, O-GlcNAcylation of the kinase RIPK3 blocks RHIM-domain-mediated protein interaction and downstream signaling activation.

Original languageEnglish (US)
Pages (from-to)576-590.e6
JournalImmunity
Volume50
Issue number3
DOIs
StatePublished - Mar 19 2019

Keywords

  • HBP
  • O-GlcNAc
  • OGT
  • RIPK3
  • inflammation
  • necroptosis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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    Li, X., Gong, W., Wang, H., Li, T., Attri, K. S., Lewis, R. E., Kalil, A. C., Bhinderwala, F., Powers, R., Yin, G., Herring, L. E., Asara, J. M., Lei, Y. L., Yang, X., Rodriguez, D. A., Yang, M., Green, D. R., Singh, P. K., & Wen, H. (2019). O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3. Immunity, 50(3), 576-590.e6. https://doi.org/10.1016/j.immuni.2019.01.007