OB-fold Families of Genome Guardians: A Universal Theme Constructed From the Small β-barrel Building Block

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

The maintenance of genome stability requires the coordinated actions of multiple proteins and protein complexes, that are collectively known as genome guardians. Within this broadly defined family is a subset of proteins that contain oligonucleotide/oligosaccharide-binding folds (OB-fold). While OB-folds are widely associated with binding to single-stranded DNA this view is no longer an accurate depiction of how these domains are utilized. Instead, the core of the OB-fold is modified and adapted to facilitate binding to a variety of DNA substrates (both single- and double-stranded), phospholipids, and proteins, as well as enabling catalytic function to a multi-subunit complex. The flexibility accompanied by distinctive oligomerization states and quaternary structures enables OB-fold genome guardians to maintain the integrity of the genome via a myriad of complex and dynamic, protein-protein; protein-DNA, and protein-lipid interactions in both prokaryotes and eukaryotes.

Original languageEnglish (US)
Article number784451
JournalFrontiers in Molecular Biosciences
Volume9
DOIs
StatePublished - Feb 11 2022

Keywords

  • BRCA2
  • MCM
  • OB-fold
  • PXXP
  • SBB family
  • SH3 domain
  • genome guardian

ASJC Scopus subject areas

  • Biochemistry
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Molecular Biology

Fingerprint

Dive into the research topics of 'OB-fold Families of Genome Guardians: A Universal Theme Constructed From the Small β-barrel Building Block'. Together they form a unique fingerprint.

Cite this