Occurrence of trisomy 12, t(14;18)(q32;q21), and t(8;14)(q24.1;q11.2) in a patient with B-cell chronic lymphocytic leukemia

Lai Ching Lau; Ping Lim; Yik Chen Lim; Li Min Teng; Tse Hui Lim; Lay Cheng Lim; Soo Yong Tan; Soon Tiong Lim; Warren G. Sanger; Sim Leng Tien

doi:10.1016/j.cancergencyto.2008.04.017

Occurrence of trisomy 12, t(14;18)(q32;q21), and t(8;14)(q24.1;q11.2) in a patient with B-cell chronic lymphocytic leukemia

Lai Ching Lau, Ping Lim, Yik Chen Lim, Li Min Teng, Tse Hui Lim, Lay Cheng Lim, Soo Yong Tan, Soon Tiong Lim, Warren G. Sanger, Sim Leng Tien

Cytogenetics

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Trisomy 12, t(14;18)(q32;q21), and t(8;14)(q24.1;q11.2) were found in a 59-year-old man with B-cell chronic lymphocytic leukemia (CLL). While trisomy 12 is one of the most common cytogenetic abnormalities in chronic lymphocytic leukemia, the t(14;18) rearrangement has a strong association with follicular lymphoma and the t(8;14) is associated with T-cell neoplasia. Occurrence of these three abnormalities in CLL are rare, and the significance of this finding is unclear. Further studies of similar cases may shed additional insight into this finding.

Original language	English (US)
Pages (from-to)	95-101
Number of pages	7
Journal	Cancer genetics and cytogenetics
Volume	185
Issue number	2
DOIs	https://doi.org/10.1016/j.cancergencyto.2008.04.017
State	Published - Sep 2008

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

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10.1016/j.cancergencyto.2008.04.017

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title = "Occurrence of trisomy 12, t(14;18)(q32;q21), and t(8;14)(q24.1;q11.2) in a patient with B-cell chronic lymphocytic leukemia",

abstract = "Trisomy 12, t(14;18)(q32;q21), and t(8;14)(q24.1;q11.2) were found in a 59-year-old man with B-cell chronic lymphocytic leukemia (CLL). While trisomy 12 is one of the most common cytogenetic abnormalities in chronic lymphocytic leukemia, the t(14;18) rearrangement has a strong association with follicular lymphoma and the t(8;14) is associated with T-cell neoplasia. Occurrence of these three abnormalities in CLL are rare, and the significance of this finding is unclear. Further studies of similar cases may shed additional insight into this finding.",

author = "Lau, {Lai Ching} and Ping Lim and Lim, {Yik Chen} and Teng, {Li Min} and Lim, {Tse Hui} and Lim, {Lay Cheng} and Tan, {Soo Yong} and Lim, {Soon Tiong} and Sanger, {Warren G.} and Tien, {Sim Leng}",

year = "2008",

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doi = "10.1016/j.cancergencyto.2008.04.017",

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volume = "185",

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journal = "Cancer genetics and cytogenetics",

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AU - Lau, Lai Ching

AU - Lim, Ping

AU - Lim, Yik Chen

AU - Teng, Li Min

AU - Lim, Tse Hui

AU - Lim, Lay Cheng

AU - Tan, Soo Yong

AU - Lim, Soon Tiong

AU - Sanger, Warren G.

AU - Tien, Sim Leng

PY - 2008/9

Y1 - 2008/9

N2 - Trisomy 12, t(14;18)(q32;q21), and t(8;14)(q24.1;q11.2) were found in a 59-year-old man with B-cell chronic lymphocytic leukemia (CLL). While trisomy 12 is one of the most common cytogenetic abnormalities in chronic lymphocytic leukemia, the t(14;18) rearrangement has a strong association with follicular lymphoma and the t(8;14) is associated with T-cell neoplasia. Occurrence of these three abnormalities in CLL are rare, and the significance of this finding is unclear. Further studies of similar cases may shed additional insight into this finding.

AB - Trisomy 12, t(14;18)(q32;q21), and t(8;14)(q24.1;q11.2) were found in a 59-year-old man with B-cell chronic lymphocytic leukemia (CLL). While trisomy 12 is one of the most common cytogenetic abnormalities in chronic lymphocytic leukemia, the t(14;18) rearrangement has a strong association with follicular lymphoma and the t(8;14) is associated with T-cell neoplasia. Occurrence of these three abnormalities in CLL are rare, and the significance of this finding is unclear. Further studies of similar cases may shed additional insight into this finding.

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Occurrence of trisomy 12, t(14;18)(q32;q21), and t(8;14)(q24.1;q11.2) in a patient with B-cell chronic lymphocytic leukemia

Abstract

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