Abstract
We have investigated the acute and sustained hemodynamic effects of octreotide on hepatic metastases of midgut carcinoids using contrast-enhanced dynamic magnetic resonance imaging (MRI). Seven patients with the carcinoid syndrome and metastasized midgut carcinoid tumors underwent functional dynamic multi-phase gadolinium-enhanced MRI of selected liver metastases at baseline and 60 min after the subcutaneous (s.c.) administration of 100 μg octreotide, and also after 3 months with three times daily (t.i.d.) 100 μg octreotide s.c. Baseline MRIs showed the typical aspect of carcinoid liver metastases with a very bright signal on the T2-weighted sequences and intense enhancement in the arterial phase after injection of gadolinium-diethylenetriamine-pentaacetate. MRIs 60 min after the s.c. administration of 100 μg octreotide showed a 34.9 ± 6.2% (mean ± SD) reduction in relative enhancement in the selected liver metastases as compared to baseline. In 2 patients, however, there was no (significant) reduction in the relative enhancement in the selected liver metastases 60 min after the s.c. administration of 100 μg octreotide as compared to baseline. Only in 2 patients did the MRIs at 3 months show a decrease in relative enhancement in one of the selected liver metastases. At 3 months, with 100 μg octreotide s.c. t.i.d., there was no correlation between the change in relative enhancement on MRI and the change in 24-hour 5-HIAA excretion. There is thus only an acute effect of octreotide on the perfusion of liver metastases. This study further shows that contrast-enhanced dynamic MRI can be a very useful tool for studying hemodynamic effects of medical therapies on liver metastases in patients with metastatic midgut carcinoids.
Original language | English (US) |
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Pages (from-to) | 41-48 |
Number of pages | 8 |
Journal | Neuroendocrinology |
Volume | 82 |
Issue number | 1 |
DOIs | |
State | Published - 2005 |
Externally published | Yes |
Keywords
- Carcinoid syndrome
- Clinical neuroendocrinology
- Liver
- Magnetic resonance imaging
- Neuroendocrine tumors
- Octreotide
- Somatostatin analogs
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Endocrinology
- Endocrine and Autonomic Systems
- Cellular and Molecular Neuroscience