Of rats and men: A translational model to understand vancomycin pharmacokinetic/toxicodynamic relationships

Marc H. Scheetz, Gwendolyn M. Pais, Thomas P. Lodise, Steven Y.C. Tong, Joshua S. Davis, J. Nicholas O'Donnell, Jiajun Liu, Michael Neely, Walter C. Prozialeck, Peter C. Lamar, Nathaniel J. Rhodes, Thomas Holland, Sean N. Avedissian

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Vancomycin area under the concentration curve (AUC) is known to predict vancomycin-induced acute kidney injury (AKI). Data were analyzed from a rat model (n = 48) and two prospective clinical studies (PROVIDE [n = 263] and CAMERA2 [n = 291]). A logit-link model was used to calculate the multiplicative factors between the probability of AKI from clinical studies and in the rat. The rat was 2.7 to 4.2 times more sensitive to AKI between AUCs of 199.5 and 794.3 mg․h/liter, respectively.

Original languageEnglish (US)
Article numbere01060-21
JournalAntimicrobial Agents and Chemotherapy
Volume65
Issue number10
DOIs
StatePublished - Oct 2021

Keywords

  • AKI
  • Allometric
  • Biomarkers
  • CAMERA2
  • Glycopeptides
  • Laboratory animals
  • PROVIDE
  • Preclinical
  • Toxicity
  • Vancomycin

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Fingerprint

Dive into the research topics of 'Of rats and men: A translational model to understand vancomycin pharmacokinetic/toxicodynamic relationships'. Together they form a unique fingerprint.

Cite this