“Omics” data unveil early molecular response underlying limb regeneration in the Chinese mitten crab, Eriocheir sinensis

Jun Wang, Xiaowen Chen, Xin Hou, Jingan Wang, Wucheng Yue, Shu Huang, Gangchun Xu, Jizhou Yan, Guoqing Lu, Michael Hofreiter, Chenhong Li, Chenghui Wang

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Limb regeneration is a fascinating and medically interesting trait that has been well preserved in arthropod lineages, particularly in crustaceans. However, the molecular mechanisms underlying arthropod limb regeneration remain largely elusive. The Chinese mitten crab Eriocheir sinensis shows strong regenerative capacity, a trait that has likely allowed it to become a worldwide invasive species. Here, we report a chromosome-level genome of E. sinensis as well as large-scale transcriptome data during the limb regeneration process. Our results reveal that arthropod-specific genes involved in signal transduction, immune response, histone methylation, and cuticle development all play fundamental roles during the regeneration process. Particularly, Innexin2-mediated signal transduction likely facilitates the early stage of the regeneration process, while an effective crustacean-specific prophenoloxidase system (ProPo-AS) plays crucial roles in the initial immune response. Collectively, our findings uncover novel genetic pathways pertaining to arthropod limb regeneration and provide valuable resources for studies on regeneration from a comparative perspective.

Original languageEnglish (US)
Article numbereabl4642
JournalScience Advances
Volume8
Issue number37
DOIs
StatePublished - Sep 2022

ASJC Scopus subject areas

  • General

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