@inproceedings{ac0302d17b3946a794a6309e1d4dcbd7,
title = "On Identifying Candidates for Drug Repurposing for the Treatment of Ulcerative Colitis using Gene Expression Data",
abstract = "The notion of repurposing of existing drugs to treat both common and rare diseases has gained traction from both academia and pharmaceutical companies. Given the high attrition rates, massive time, money, and effort of brand-new drug development, the advantages of drug repurposing in terms of lower costs and shorter development time have become more appealing. Computational drug repurposing is promising approach and has shown great potential in tailoring genomic findings to the development of treatments for diseases. However, there are still challenges involved in building a standard computational drug repurposing solution for high-throughput analysis and the implementation to clinical practice. In this study, we applied the computational drug repurposing approaches for Ulcerative Colitis (UC) patients to provide better treatment for this disabling disease. Repositioning drug candidates were identified, and these findings provide a potentially effective therapeutics for the treatment of UC patients. This preliminary computational drug repurposing pipeline will be extended in the near future to help realize the full potential of drug repurposing.",
keywords = "Computational tools, Drug repurposing, Gene expression data, Next generation healthcare, Systems biology",
author = "Suyeon Kim and Ishwor Thapa and Ling Zhang and Hesham Ali",
note = "Publisher Copyright: {\textcopyright} 2019, Springer Nature Switzerland AG.; 7th International Work-Conference on Bioinformatics and Biomedical Engineering, IWBBIO 2019 ; Conference date: 08-05-2019 Through 10-05-2019",
year = "2019",
doi = "10.1007/978-3-030-17938-0_45",
language = "English (US)",
isbn = "9783030179373",
series = "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",
publisher = "Springer Verlag",
pages = "513--521",
editor = "Olga Valenzuela and Fernando Rojas and Francisco Ortu{\~n}o and Francisco Ortu{\~n}o and Ignacio Rojas",
booktitle = "Bioinformatics and Biomedical Engineering - 7th International Work-Conference, IWBBIO 2019, Proceedings",
}