On identifying effective and superior drug combinations via Holm's procedure based on the Min tests

Julia N. Soulakova

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

In this paper I consider a problem of identifying all effective and superior drug combinations. I formulate this problem in terms of a family of hypotheses and propose a two-stage method to solve it. The first stage uses individual p-values obtained via the Min tests, whereas Holm's approach is employed in the second stage to draw simultaneous inferences. This procedure is shown to control the family-wise error rate in a strong sense. The performance of the procedure is studied by simulation for different parameter settings. The conclusions of the simulation study are stated in terms of the power, family-wise error rate and lack of power.

Original languageEnglish (US)
Pages (from-to)280-291
Number of pages12
JournalJournal of Biopharmaceutical Statistics
Volume19
Issue number2
DOIs
StatePublished - Mar 2009

Keywords

  • Closed testing
  • Dose-response
  • Minimum effective dose
  • Multiple testing
  • Step-down procedure

ASJC Scopus subject areas

  • Statistics and Probability
  • Pharmacology
  • Pharmacology (medical)

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