Oncology: The role of partial nephrectomy in wilms tumor

Miriam Harel, John H. Makari, Fernando A. Ferrer

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Wilms tumor represents the most common pediatric renal malignancy and the fourth most common childhood cancer overall. Overall survival from Wilms tumor has increased to over 90 % secondary to multidisciplinary therapy and multi-institutional cooperative group trials. Recent therapeutic focus has shifted to reduction in treatment morbidity and renal preservation while maintaining the high survival rates. Partial nephrectomy is an integral component of the multimodal treatment protocols for Wilms tumor patients with bilateral disease, solitary kidney, or predisposing syndromes. Recent consideration has been given to utilization of nephron sparing surgery (NSS) in carefully selected patients with nonsyndromic unilateral Wilms tumor. While long-term, prospective data in this subgroup of patients is not yet available, case series demonstrate comparable oncologic outcomes after partial versus radical nephrectomy. The relative rarity of Wilms tumor, especially those amenable to upfront partial nephrectomy, presents a challenge to conducting controlled trials.

Original languageEnglish (US)
Pages (from-to)350-358
Number of pages9
JournalCurrent Urology Reports
Volume14
Issue number4
DOIs
StatePublished - Aug 2013
Externally publishedYes

Keywords

  • Nephron sparing surgery
  • Partial nephrectomy
  • Renal function
  • Wilms tumor

ASJC Scopus subject areas

  • Urology

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