Abstract
An efficient one-pot asymmetric synthesis of highly substituted γ-lactams containing α-methylene groups has been successfully developed. A wide range of γ-lactams could be obtained in high yields with excellent diastereomeric ratios of up to 99:1 in favor of trans isomers. In particular, excellent enantioselectivities of the two newly formed stereogenic centers with up to 99% ee were observed.
Original language | English (US) |
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Pages (from-to) | 5154-5157 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 12 |
Issue number | 22 |
DOIs | |
State | Published - Nov 19 2010 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry