One-pot synthesis of chiral α-methylene-γ-lactams with excellent diastereoselectivities and enantioselectivities

An Shen, Min Liu, Zhen Shan Jia, Ming Hua Xu, Guo Qiang Lin

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

An efficient one-pot asymmetric synthesis of highly substituted γ-lactams containing α-methylene groups has been successfully developed. A wide range of γ-lactams could be obtained in high yields with excellent diastereomeric ratios of up to 99:1 in favor of trans isomers. In particular, excellent enantioselectivities of the two newly formed stereogenic centers with up to 99% ee were observed.

Original languageEnglish (US)
Pages (from-to)5154-5157
Number of pages4
JournalOrganic Letters
Volume12
Issue number22
DOIs
StatePublished - Nov 19 2010

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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