Open reading frame 2, encoded by the latency-related gene of bovine herpesvirus 1, has antiapoptotic activity in transiently transfected neuroblastoma cells

Wenwen Shen, Clinton Jones

Research output: Contribution to journalArticle

24 Scopus citations


The latency-related (LR) RNA encoded by bovine herpesvirus 1 is abundantly expressed in the trigeminal ganglia of latently infected calves. Expression of LR proteins is necessary for reactivation from latency and the protection of infected neurons from apoptosis. In this study, we demonstrated that an LR-encoded protein, open reading frame 2 (ORF-2), or ORF-2 fusion proteins encoded by alternatively spliced LR transcripts inhibit cold shock or Fas ligand-induced apoptosis in mouse neuroblastoma (neuro-2A) cells. Frameshift mutants of ORF-2 do not inhibit apoptosis, which suggests that protein expression, not LR RNA expression, mediates the antiapoptotic activity of the LR gene in transfected neuro-2A cells.

Original languageEnglish (US)
Pages (from-to)10940-10945
Number of pages6
JournalJournal of virology
Issue number21
Publication statusPublished - Nov 1 2008


ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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