Opiates, immune system, acquired immunodeficiency syndrome, and nonhuman primate model

Richard Noel; Vanessa Rivera-Amill; Shilpa Buch; Anil Kumar

doi:10.1080/13550280802078209

Opiates, immune system, acquired immunodeficiency syndrome, and nonhuman primate model

Richard Noel, Vanessa Rivera-Amill, Shilpa Buch, Anil Kumar

Research output: Contribution to journal › Review article › peer-review

19 Scopus citations

Abstract

Both human immunodeficiency virus (HIV) and illicit drug addiction remain major health problems not only in the United States but all over globe. The effect of drug addiction on HIV/AIDS (acquired immunodeficiency syndrome) has been somewhat underexplored. However, in United States more than one fourth of HIV-positive individuals are injection drug users. Opiates are known to negatively affect the immune system, and therefore may have deleterious effects on progression of disease among HIV-infected individuals. This review discusses the effects of opiates on immune system as well as its effect on HIV replication and AIDS progression. In addition, the effects of opiates on disease progression in non-human primate model of AIDS is presented with at least one possible reason for rapid disease progression in multi-virus the challenge model.

Original language	English (US)
Pages (from-to)	279-285
Number of pages	7
Journal	Journal of neurovirology
Volume	14
Issue number	4
DOIs	https://doi.org/10.1080/13550280802078209
State	Published - 2008
Externally published	Yes

Keywords

HIV
Macaque
Morphine
SHIV
SIV

ASJC Scopus subject areas

Neurology
Clinical Neurology
Cellular and Molecular Neuroscience
Virology

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10.1080/13550280802078209

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abstract = "Both human immunodeficiency virus (HIV) and illicit drug addiction remain major health problems not only in the United States but all over globe. The effect of drug addiction on HIV/AIDS (acquired immunodeficiency syndrome) has been somewhat underexplored. However, in United States more than one fourth of HIV-positive individuals are injection drug users. Opiates are known to negatively affect the immune system, and therefore may have deleterious effects on progression of disease among HIV-infected individuals. This review discusses the effects of opiates on immune system as well as its effect on HIV replication and AIDS progression. In addition, the effects of opiates on disease progression in non-human primate model of AIDS is presented with at least one possible reason for rapid disease progression in multi-virus the challenge model.",

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AU - Kumar, Anil

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AB - Both human immunodeficiency virus (HIV) and illicit drug addiction remain major health problems not only in the United States but all over globe. The effect of drug addiction on HIV/AIDS (acquired immunodeficiency syndrome) has been somewhat underexplored. However, in United States more than one fourth of HIV-positive individuals are injection drug users. Opiates are known to negatively affect the immune system, and therefore may have deleterious effects on progression of disease among HIV-infected individuals. This review discusses the effects of opiates on immune system as well as its effect on HIV replication and AIDS progression. In addition, the effects of opiates on disease progression in non-human primate model of AIDS is presented with at least one possible reason for rapid disease progression in multi-virus the challenge model.

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Opiates, immune system, acquired immunodeficiency syndrome, and nonhuman primate model

Abstract

Keywords

ASJC Scopus subject areas

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