Optic nerve hypoplasia: A retrospective analysis of clinical presentation and disease severity

Audrey N. Netzel, Robin High, Donny W. Suh

Research output: Contribution to journalArticle

Abstract

Purpose: Through the establishment of relationships between optic nerve hypoplasia (ONH), optical coherence tomography (OCT) spectralis retinal nerve fiber layer (RNFL) thickness results and clinical sequelae, this study aims to identify long-term outcomes for individuals with ONH. Methods: A retrospective review of pediatric ophthalmology patients at Children’s Hospital of Omaha from January 2000 to October 2018 was performed. All patients with ONH evaluated with Heidelberg Engineering’s OCT Spectralis were identified. Patient records were investigated for visual acuity, presence of nystagmus, strabismus, and endocrinopathies. Statistical analysis with linear regression models, random intercepts models, and odds ratios were used to define relationships between RNFL thickness at the optic nerve head, nystagmus, strabismus, and endocrine dysfunction. Results: There exists a strong trend of worsening visual acuity as RNFL thickness at the optic nerve head decreases in all scanned regions. This is strongest at the temporal-superior (p=0.009) and nasal-inferior (p=0.006) regions in patients with bilateral ONH. There is insufficient evidence of a difference in prevalence of nystagmus or strabismus between subjects with unilateral or bilateral ONH. Endocrinopathy is present in 21.6% of the subjects, with no statistical difference in the type of endocrinopathy or laterality of ONH. Conclusion: Trends established indicate that best-corrected visual acuity is related to RNFL thickness at the optic nerve head. Odds ratios for the prevalence of nystagmus also point to RNFL thickness as a contributing factor. These trends may have the potential to characterize ONH severity by objective measurement of clinical outcomes and RNFL thickness at the optic nerve head.

Original languageEnglish (US)
Pages (from-to)2607-2616
Number of pages10
JournalClinical Ophthalmology
Volume13
DOIs
StatePublished - 2019

Keywords

  • Optic nerve hypoplasia
  • Optical coherence tomography
  • Retinal nerve fiber layer thickness

ASJC Scopus subject areas

  • Ophthalmology

Fingerprint Dive into the research topics of 'Optic nerve hypoplasia: A retrospective analysis of clinical presentation and disease severity'. Together they form a unique fingerprint.

  • Cite this