Optical coherence tomography: A new method to assess aneurysm healing

William E. Thorell, Michael M. Chow, Richard A. Prayson, Mark A. Shure, Sung W. Jeon, David Huang, Emil Zeynalov, Henry H. Woo, Peter A. Rasmussen, Andrew M. Rollins, Thomas J. Masaryk

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Object. Aneurysmal subarachnoid hemorrhage affects approximately 10/100,000 people per year. Endovascular coil embolization is used increasingly to treat cerebral aneurysms and its safety and durability is rapidly developing. The long-term durability of coil embolization of cerebral aneurysms remains in question; patients treated using this modality require multiple follow-up angiography studies and occasional repeated treatments. Methods. Optical coherence tomography (OCT) is an emerging imaging modality that uses backscattered light to produce high-resolution tomography of optically accessible biological tissues such as the eye, luminal surface of blood vessels, and gastrointestinal tract. Vascular OCT probes in the form of imaging microwires are presently available - although not Food and Drug Administration-approved - and may be adapted for use in the cerebral circulation. In this study the authors describe the initial use of OCT to make visible the neck of aneurysms created in a canine model and treated with coil embolization. Optical coherence tomography images demonstrate changes that correlate with the histological findings of healing at the aneurysm neck and thus may be capable of demonstrating human cerebral aneurysm healing. Conclusions. Optical coherence tomography may obviate the need for subsequent follow-up angiography studies as well as aid in the understanding of endovascular tissue healing. Data in this study demonstrate that further investigation of in vivo imaging with such probes is warranted.

Original languageEnglish (US)
Pages (from-to)348-354
Number of pages7
JournalJournal of neurosurgery
Issue number2
StatePublished - Feb 2005
Externally publishedYes


  • Dog
  • Endovascular therapy
  • Intracranial aneurysm
  • Optical coherence tomography

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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