Optimizing the osteogenic potential of adult stem cells for skeletal regeneration

Jung Yul Lim, Alayna E. Loiselle, Jeong Soon Lee, Yue Zhang, Joshua D. Salvi, Henry J. Donahue

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations


Adult stem cells, including mesenchymal stem cells, display plasticity in that they can differentiate toward various lineages including bone cells, cartilage cells, fat cells, and other types of connective tissue cells. However, it is not clear what factors direct adult stem cell lineage commitment and terminal differentiation. Emerging evidence suggests that extracellular physical cues have the potential to control stem cell lineage specification. In this perspective article, we review recent findings on biomaterial surface and mechanical signal regulation of stem cell differentiation. Specifically, we focus on stem cell response to substrate nanoscale topography and fluid flow induced shear stress and how these physical factors may regulate stem cell osteoblastic differentiation in vitro.

Original languageEnglish (US)
Pages (from-to)1627-1633
Number of pages7
JournalJournal of Orthopaedic Research
Issue number11
StatePublished - Nov 2011


  • fluid flow
  • mechanotransduction
  • nanotopography
  • stem cells
  • tissue engineering

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine


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