Oral Bioavailability of Creatine Supplements: Insights into Mechanism and Implications for Improved Absorption

Donald W. Miller; Samuel Augustine; Dennis H. Robinson; Jonathan L. Vennerstrom; Jon C. Wagner

doi:10.1016/B978-0-12-396454-0.00040-0

Oral Bioavailability of Creatine Supplements: Insights into Mechanism and Implications for Improved Absorption

Donald W. Miller, Samuel Augustine, Dennis H. Robinson, Jonathan L. Vennerstrom, Jon C. Wagner

Pharmaceutical Science

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Creatine supplements have a long history of use for improving muscle performance. While there are a number of studies that document the effects of creatine supplementation on muscle strength and performance, there are relatively few studies examining oral bioavailability. Despite early studies suggesting nearly complete oral absorption of creatine monohydrate, there are a number of reasons to suggest creatine absorption from the gastrointestinal tract is far from complete and that significant improvements in bioavailability can be obtained. This review examines the mechanisms controlling creatine absorption in the intestine and the implications for improving the bioavailability of creatine supplements.

Original language	English (US)
Title of host publication	Nutrition and Enhanced Sports Performance
Subtitle of host publication	Muscle Building, Endurance, and Strength
Publisher	Elsevier Inc.
Pages	395-403
Number of pages	9
ISBN (Print)	9780123964540
DOIs	https://doi.org/10.1016/B978-0-12-396454-0.00040-0
State	Published - Aug 2013

Keywords

Creatine bioavailability
Creatine ester
Creatine salts
Oral absorption
Paracellular diffusion

ASJC Scopus subject areas

General Agricultural and Biological Sciences
General Biochemistry, Genetics and Molecular Biology
General Medicine

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10.1016/B978-0-12-396454-0.00040-0

Cite this

Miller, D. W., Augustine, S., Robinson, D. H., Vennerstrom, J. L., & Wagner, J. C. (2013). Oral Bioavailability of Creatine Supplements: Insights into Mechanism and Implications for Improved Absorption. In Nutrition and Enhanced Sports Performance: Muscle Building, Endurance, and Strength (pp. 395-403). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-396454-0.00040-0

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abstract = "Creatine supplements have a long history of use for improving muscle performance. While there are a number of studies that document the effects of creatine supplementation on muscle strength and performance, there are relatively few studies examining oral bioavailability. Despite early studies suggesting nearly complete oral absorption of creatine monohydrate, there are a number of reasons to suggest creatine absorption from the gastrointestinal tract is far from complete and that significant improvements in bioavailability can be obtained. This review examines the mechanisms controlling creatine absorption in the intestine and the implications for improving the bioavailability of creatine supplements.",

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T2 - Insights into Mechanism and Implications for Improved Absorption

AU - Miller, Donald W.

AU - Augustine, Samuel

AU - Robinson, Dennis H.

AU - Vennerstrom, Jonathan L.

AU - Wagner, Jon C.

PY - 2013/8

Y1 - 2013/8

N2 - Creatine supplements have a long history of use for improving muscle performance. While there are a number of studies that document the effects of creatine supplementation on muscle strength and performance, there are relatively few studies examining oral bioavailability. Despite early studies suggesting nearly complete oral absorption of creatine monohydrate, there are a number of reasons to suggest creatine absorption from the gastrointestinal tract is far from complete and that significant improvements in bioavailability can be obtained. This review examines the mechanisms controlling creatine absorption in the intestine and the implications for improving the bioavailability of creatine supplements.

AB - Creatine supplements have a long history of use for improving muscle performance. While there are a number of studies that document the effects of creatine supplementation on muscle strength and performance, there are relatively few studies examining oral bioavailability. Despite early studies suggesting nearly complete oral absorption of creatine monohydrate, there are a number of reasons to suggest creatine absorption from the gastrointestinal tract is far from complete and that significant improvements in bioavailability can be obtained. This review examines the mechanisms controlling creatine absorption in the intestine and the implications for improving the bioavailability of creatine supplements.

KW - Creatine bioavailability

KW - Creatine ester

KW - Creatine salts

KW - Oral absorption

KW - Paracellular diffusion

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BT - Nutrition and Enhanced Sports Performance

PB - Elsevier Inc.

ER -

Oral Bioavailability of Creatine Supplements: Insights into Mechanism and Implications for Improved Absorption

Abstract

Keywords

ASJC Scopus subject areas

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