Oral Bioavailability of Creatine Supplements: Insights Into Mechanism and Implications for Improved Absorption

Eman A. Alraddadi; Samuel Augustine; Dennis H. Robinson; Jonathan L. Vennerstrom; Jon C. Wagner; Donald W. Miller

doi:10.1016/B978-0-12-813922-6.00050-3

Oral Bioavailability of Creatine Supplements: Insights Into Mechanism and Implications for Improved Absorption

Eman A. Alraddadi, Samuel Augustine, Dennis H. Robinson, Jonathan L. Vennerstrom, Jon C. Wagner, Donald W. Miller

Pharmaceutical Science

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Creatine supplements have a long history of use for improving muscle performance. While there are a number of studies that document the effects of creatine supplementation on muscle strength and performance, there are relatively few studies examining oral bioavailability. Despite early studies suggesting nearly complete oral absorption of creatine monohydrate, there are a number of findings that suggest that creatine absorption from the gastrointestinal tract is far from complete and that significant improvements in bioavailability can be obtained. This review examines the mechanisms controlling creatine absorption in the intestine and implications for improving the bioavailability of creatine supplements.

Original language	English (US)
Title of host publication	Nutrition and Enhanced Sports Performance
Subtitle of host publication	Muscle Building, Endurance, and Strength
Publisher	Elsevier
Pages	595-604
Number of pages	10
ISBN (Print)	9780128139226
DOIs	https://doi.org/10.1016/B978-0-12-813922-6.00050-3
State	Published - Oct 10 2018

Keywords

Creatine bioavailability
Creatine ester
Creatine salts
Oral absorption
Paracellular diffusion

ASJC Scopus subject areas

General Engineering
General Agricultural and Biological Sciences

Access to Document

10.1016/B978-0-12-813922-6.00050-3

Cite this

Alraddadi, E. A., Augustine, S., Robinson, D. H., Vennerstrom, J. L., Wagner, J. C., & Miller, D. W. (2018). Oral Bioavailability of Creatine Supplements: Insights Into Mechanism and Implications for Improved Absorption. In Nutrition and Enhanced Sports Performance: Muscle Building, Endurance, and Strength (pp. 595-604). Elsevier. https://doi.org/10.1016/B978-0-12-813922-6.00050-3

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abstract = "Creatine supplements have a long history of use for improving muscle performance. While there are a number of studies that document the effects of creatine supplementation on muscle strength and performance, there are relatively few studies examining oral bioavailability. Despite early studies suggesting nearly complete oral absorption of creatine monohydrate, there are a number of findings that suggest that creatine absorption from the gastrointestinal tract is far from complete and that significant improvements in bioavailability can be obtained. This review examines the mechanisms controlling creatine absorption in the intestine and implications for improving the bioavailability of creatine supplements.",

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T2 - Insights Into Mechanism and Implications for Improved Absorption

AU - Alraddadi, Eman A.

AU - Augustine, Samuel

AU - Robinson, Dennis H.

AU - Vennerstrom, Jonathan L.

AU - Wagner, Jon C.

AU - Miller, Donald W.

PY - 2018/10/10

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N2 - Creatine supplements have a long history of use for improving muscle performance. While there are a number of studies that document the effects of creatine supplementation on muscle strength and performance, there are relatively few studies examining oral bioavailability. Despite early studies suggesting nearly complete oral absorption of creatine monohydrate, there are a number of findings that suggest that creatine absorption from the gastrointestinal tract is far from complete and that significant improvements in bioavailability can be obtained. This review examines the mechanisms controlling creatine absorption in the intestine and implications for improving the bioavailability of creatine supplements.

AB - Creatine supplements have a long history of use for improving muscle performance. While there are a number of studies that document the effects of creatine supplementation on muscle strength and performance, there are relatively few studies examining oral bioavailability. Despite early studies suggesting nearly complete oral absorption of creatine monohydrate, there are a number of findings that suggest that creatine absorption from the gastrointestinal tract is far from complete and that significant improvements in bioavailability can be obtained. This review examines the mechanisms controlling creatine absorption in the intestine and implications for improving the bioavailability of creatine supplements.

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KW - Creatine ester

KW - Creatine salts

KW - Oral absorption

KW - Paracellular diffusion

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Oral Bioavailability of Creatine Supplements: Insights Into Mechanism and Implications for Improved Absorption

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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