Oral cavity reconstruction outcomes using a porcine urinary bladder matrix: A retrospective case series

Jed H. Assam, William C. Spanos

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Objective. The purpose of this study is to assess healing outcomes in full-thickness mucosal wounds following the use of a porcine urinary bladder matrix to augment mixed oral cavity repairs. Materials and Methods. A retrospective chart analysis was conducted over a 58-month timespan. Participants included individuals with osteoradionecrosis. Descriptive measures obtained in the postoperative setting were used to examine wound healing outcomes. Results. Thirty-nine encounters with 35 patients met inclusion criteria for assessment. The mean defect size repaired was 14 cm2. Successful healing occurred in 64% of cases. Scarring was observed in 10 cases, and 3 cases demonstrated transient functional deficits. Reapplication of the xenograft was required in 4 cases. Only 1 acute event of hemorrhage and 1 infection were observed in the postoperative period. Conclusions. Use of porcine urinary bladder matrix grafts for oral cavity reconstruction was well tolerated in a diverse number of wound scenarios with a relatively low risk of postoperative complication. The use of porcine urinary bladder matrix was not observed to provide any noteworthy advantages for the healing of recalcitrant osteoradionecrosis wounds.

Original languageEnglish (US)
Pages (from-to)131-137
Number of pages7
Issue number5
StatePublished - May 2018
Externally publishedYes


  • Biologic scaffold
  • MatriStem
  • Oral
  • Porcine urinary bladder matrix
  • Reconstruction

ASJC Scopus subject areas

  • Surgery
  • Medical–Surgical


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