Oral Delivery of Nucleic Acid Therapies for Local and Systemic Action

Neha Kumari, Kasturi Siddhanta, Sudipta Panja, Vineet Joshi, Chinmay Jogdeo, Ekta Kapoor, Rubayat Khan, Sai Sundeep Kollala, Balawant Kumar, Diptesh Sil, Amar B. Singh, Daryl J. Murry, David Oupický

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Nucleic acid (NA) therapy has gained importance over the past decade due to its high degree of selectivity and minimal toxic effects over conventional drugs. Currently, intravenous (IV) or intramuscular (IM) formulations constitute majority of the marketed formulations containing nucleic acids. However, oral administration is traditionally preferred due to ease of administration as well as higher patient compliance. To leverage the benefits of oral delivery for NA therapy, the NA of interest must be delivered to the target site avoiding all degrading and inhibiting factors during its transition through the gastrointestinal tract. The oral route presents myriad of challenges to NA delivery, making formulation development challenging. Researchers in the last few decades have formulated various delivery systems to overcome such challenges and several reviews summarize and discuss these strategies in detail. However, there is a need to differentiate between the approaches based on target so that in future, delivery strategies can be developed according to the goal of the study and for efficient delivery to the desired site. The goal of this review is to summarize the mechanisms for target specific delivery, list and discuss the formulation strategies used for oral delivery of NA therapies and delineate the similarities and differences between local and systemic targeting oral delivery systems and current challenges.

Original languageEnglish (US)
Pages (from-to)107-122
Number of pages16
JournalPharmaceutical Research
Issue number1
StatePublished - Jan 2023


  • gastrointestinal diseases
  • local target
  • nucleic acids
  • oral delivery
  • systemic target

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry
  • Pharmacology (medical)


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