Abstract
Photothermal therapy exerts its anticancer effect by converting laser radiation energy into hyperthermia using a suitable photosensitizer. This study reports development of nanostructured lipid carriers (NLCs) suitable for noninvasive oral delivery of a near-infrared photosensitizer dye IR780. The carrier encapsulating the dye (IR780@NLCs) was stable in simulated gastric and intestinal conditions and showed greatly enhanced oral absorption of IR780 when compared with the free dye. As a result of increased oral bioavailability, enhanced accumulation of the dye in subcutaneous mouse colon tumors (CT-26 cells) was observed following oral gavage of IR780@NLCs. Photothermal antitumor activity of orally administered IR780@NLCs was evaluated following local laser irradiation of the CT-26 tumors. We observed significant effect of the photothermal IR780@NLCs treatment on the rate of the tumor growth and no toxicity associated with the oral administration of IR780@NLCs. Overall, orally administered IR780@NLCs represents a safe and noninvasive method to achieve systemic tumor delivery of a photosensitizing dye for applications in photothermal anticancer therapies.
Original language | English (US) |
---|---|
Pages (from-to) | 25087-25095 |
Number of pages | 9 |
Journal | ACS Applied Materials and Interfaces |
Volume | 8 |
Issue number | 38 |
DOIs | |
State | Published - Sep 28 2016 |
Keywords
- IR780
- nanostructured lipid carriers
- oral administration
- photothermal therapy
- tumor imaging
ASJC Scopus subject areas
- Materials Science(all)